{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Deng YZ"],"funding":["Youth Innovation Promotion Association of Chinese Academy of Sciences","Shanghai Institutes for Biological Science","National Natural Science Foundation of China"],"pagination":["177-195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5748847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["215(1)"],"pubmed_abstract":["Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown. In this study, disrupted ciliogenesis was observed in cancer cells and pancreatic cancer tissues, which facilitated oncogene-induced transformation of normal pancreatic cells (HPDE6C7) and NIH3T3 cells through activating the mevalonate (MVA) pathway. Disruption of ciliogenesis up-regulated MVA enzymes through β catenin-T cell factor (TCF) signaling, which synchronized with sterol regulatory element binding transcription factor 2 (SREBP2), and the regulation of MVA by β-catenin-TCF signaling was recapitulated in a mouse model of pancreatic ductal adenocarcinoma (PDAC) and human PDAC samples. Moreover, disruption of ciliogenesis by de"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Cilia loss sensitizes cells to transformation by activating the mevalonate pathway."],"pmcid":["PMC5748847"],"funding_grant_id":["1731517600313-14","81730083","81372289","81230058","31520103907","81572750","2014KIP105"],"pubmed_authors":["Huang XX","Zhang EB","Liu LM","Shi S","Ma N","Jiang H","Feng D","Wang XF","Li DS","Chen TW","Chin E","Rong YF","Xie D","Guan DX","Qian ZY","Du YN","Cai Z","Deng YZ","Shang YR","Liu DP","Wang JJ","Zhou QL","Zhang XL"],"additional_accession":[]},"is_claimable":false,"name":"Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.","description":"Although cilia loss and cell transformation are frequently observed in the early stage of tumorigenesis, the roles of cilia in cell transformation are unknown. In this study, disrupted ciliogenesis was observed in cancer cells and pancreatic cancer tissues, which facilitated oncogene-induced transformation of normal pancreatic cells (HPDE6C7) and NIH3T3 cells through activating the mevalonate (MVA) pathway. Disruption of ciliogenesis up-regulated MVA enzymes through β catenin-T cell factor (TCF) signaling, which synchronized with sterol regulatory element binding transcription factor 2 (SREBP2), and the regulation of MVA by β-catenin-TCF signaling was recapitulated in a mouse model of pancreatic ductal adenocarcinoma (PDAC) and human PDAC samples. Moreover, disruption of ciliogenesis by de","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-05-06T00:51:37.15Z","creation":"2019-06-06T18:42:42Z"},"accession":"S-EPMC5748847","cross_references":{"pubmed":["29237705"],"doi":["10.1084/jem.20170399"]}}