biostudies-literatureKakrana ANEI NIH HHSD875-D885https://www.ebi.ac.uk/biostudies/studies/S-EPMC5753381biostudies-literatureUnknown46(D1)Although successful in identifying new cataract-linked genes, the previous version of the database iSyTE (integrated Systems Tool for Eye gene discovery) was based on expression information on just three mouse lens stages and was functionally limited to visualization by only UCSC-Genome Browser tracks. To increase its efficacy, here we provide an enhanced iSyTE version 2.0 (URL: http://research.bioinformatics.udel.edu/iSyTE) based on well-curated, comprehensive genome-level lens expression data as a one-stop portal for the effective visualization and analysis of candidate genes in lens development and disease. iSyTE 2.0 includes all publicly available lens Affymetrix and Illumina microarray datasets representing a broad range of embryonic and postnatal stages from wild-type and specific geNucleic acids researchiSyTE 2.0: a database for expression-based gene discovery in the eye.PMC5753381R01 EY021505Kakrana AHuang HDjordjevic DAnand DSingh AYang ARamachandruni DLachke SAHo JWKfalseiSyTE 2.0: a database for expression-based gene discovery in the eye.Although successful in identifying new cataract-linked genes, the previous version of the database iSyTE (integrated Systems Tool for Eye gene discovery) was based on expression information on just three mouse lens stages and was functionally limited to visualization by only UCSC-Genome Browser tracks. To increase its efficacy, here we provide an enhanced iSyTE version 2.0 (URL: http://research.bioinformatics.udel.edu/iSyTE) based on well-curated, comprehensive genome-level lens expression data as a one-stop portal for the effective visualization and analysis of candidate genes in lens development and disease. iSyTE 2.0 includes all publicly available lens Affymetrix and Illumina microarray datasets representing a broad range of embryonic and postnatal stages from wild-type and specific ge2018-01-01T00:00:00Z2018 Jan2026-05-01T07:34:59.52Z2025-06-01T12:02:31.225ZS-EPMC57533812903652710.1093/nar/gkx837