{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Durand A"],"pubmed_abstract":["Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell re"],"journal":["Nature communications"],"pagination":["68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5754350"],"repository":["biostudies-literature"],"pubmed_title":["Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota."],"pmcid":["PMC5754350"],"pubmed_authors":["Bonilla N","Guichard V","Mattiuz R","Durand A","Audemard-Verger A","Riviere M","Martin B","Lucas B","Delon J","Delpoux A","Hamon P","Boissonnas A","Auffray C"],"additional_accession":[]},"is_claimable":false,"name":"Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota.","description":"Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell re","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-05-02T17:42:34.243Z","creation":"2025-06-01T12:02:45.513Z"},"accession":"S-EPMC5754350","cross_references":{"pubmed":["29302034"],"doi":["10.1038/s41467-017-02458-4"]}}