{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Donaldson ME"],"funding":["Natural Sciences and Engineering Research Council of Canada","National Institutes of Health","NIGMS NIH HHS"],"pagination":["572-583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5756825"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Pathogens are recognized as major drivers of local adaptation in wildlife systems. By determining which gene variants are favored in local interactions among populations with and without disease, spatially explicit adaptive responses to pathogens can be elucidated. Much of our current understanding of host responses to disease comes from a small number of genes associated with an immune response. High-throughput sequencing (HTS) technologies, such as genotype-by-sequencing (GBS), facilitate expanded explorations of genomic variation among populations. Hybridization-based GBS techniques can be leveraged in systems not well characterized for specific variants associated with disease outcome to \"capture\" specific genes and regulatory regions known to influence expression and disease outcome. "],"journal":["Ecology and evolution"],"pubmed_title":["Development of a genotype-by-sequencing immunogenetic assay as exemplified by screening for variation in red fox with and without endemic rabies exposure."],"pmcid":["PMC5756825"],"funding_grant_id":["R01 GM120782","GM120782"],"pubmed_authors":["Kukekova AV","Hueffer K","Donaldson ME","Rando HM","Kyle CJ","Rico Y"],"additional_accession":[]},"is_claimable":false,"name":"Development of a genotype-by-sequencing immunogenetic assay as exemplified by screening for variation in red fox with and without endemic rabies exposure.","description":"Pathogens are recognized as major drivers of local adaptation in wildlife systems. By determining which gene variants are favored in local interactions among populations with and without disease, spatially explicit adaptive responses to pathogens can be elucidated. Much of our current understanding of host responses to disease comes from a small number of genes associated with an immune response. High-throughput sequencing (HTS) technologies, such as genotype-by-sequencing (GBS), facilitate expanded explorations of genomic variation among populations. Hybridization-based GBS techniques can be leveraged in systems not well characterized for specific variants associated with disease outcome to \"capture\" specific genes and regulatory regions known to influence expression and disease outcome. ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-05-02T08:25:00.037Z","creation":"2019-03-27T00:14:39Z"},"accession":"S-EPMC5756825","cross_references":{"pubmed":["29321894"],"doi":["10.1002/ece3.3583"]}}