{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zaucker A"],"funding":["Lundbeck Foundation","Biotechnology and Biological Sciences Research Council"],"pagination":["104-119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5758872"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(1)"],"pubmed_abstract":["In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translational co-regulation of multiple components of a developmental signaling pathway. Here, we show that an RNA element which we previously identified as a dorsal localization element (DLE) in the 3'UTR of zebrafish nodal-related1/squint (ndr1/sqt) ligand mRNA, is shared by the related ligand nodal-related2/cyclops (ndr2/cyc) and the nodal inhibitors, lefty1 (lft1) and lefty2 mRNAs. We investigated the activity of the DLEs through functional assays in live zebrafish embryos. The lft1 DLE localizes fluorescently labeled RNA similarly to the ndr1/sqt DLE. Similar to the ndr1/sqt 3'UTR, the lft1 and lft2 3'UTRs are bound"],"journal":["Nucleic acids research"],"pubmed_title":["Translational co-regulation of a ligand and inhibitor by a conserved RNA element."],"pmcid":["PMC5758872"],"funding_grant_id":["R77-2011-6365","BB/L007525/1"],"pubmed_authors":["Cooper L","VijayKumar S","Huang S","Gorodkin J","Kumari P","Zaucker A","Nagorska A","Sampath K","Wang Y","Sivashanmugam L","Hecker N","Brosens J"],"additional_accession":[]},"is_claimable":false,"name":"Translational co-regulation of a ligand and inhibitor by a conserved RNA element.","description":"In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translational co-regulation of multiple components of a developmental signaling pathway. Here, we show that an RNA element which we previously identified as a dorsal localization element (DLE) in the 3'UTR of zebrafish nodal-related1/squint (ndr1/sqt) ligand mRNA, is shared by the related ligand nodal-related2/cyclops (ndr2/cyc) and the nodal inhibitors, lefty1 (lft1) and lefty2 mRNAs. We investigated the activity of the DLEs through functional assays in live zebrafish embryos. The lft1 DLE localizes fluorescently labeled RNA similarly to the ndr1/sqt DLE. Similar to the ndr1/sqt 3'UTR, the lft1 and lft2 3'UTRs are bound","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-04-16T05:15:36.645Z","creation":"2025-06-01T00:37:05.633Z"},"accession":"S-EPMC5758872","cross_references":{"pubmed":["29059375"],"doi":["10.1093/nar/gkx938"]}}