biostudies-literatureChang Athe Winship Cancer Institute at Emory University Neil W. and William S. Elkin Fellowship to A. ChangNCI NIH HHS55-70https://www.ebi.ac.uk/biostudies/studies/S-EPMC5762391biostudies-literatureUnknown27(1)<h4>Introduction</h4>Inhibitors against the PD-1/PD-L1 pathway are revolutionizing the treatment and management of malignancies.<h4>Areas covered</h4>We summarize our current understanding of the function of PD-1, its role in immune evasion, the clinical data available that support the use of PD-1 antagonist in Hodgkin and non-Hodgkin lymphomas, and potential predictors of response.<h4>Expert opinion</h4>We anticipate that in the next 10 years, agents that modulate the immune system such as PD-1 antagonists will be increasingly used in favor over traditional cytotoxic chemotherapeutic agents. PD-1 antagonists will be combined with future immunotherapies or used as adjuncts to cellular therapy to boost tumor-specific immune responses.Expert opinion on investigational drugsInvestigational PD-1 inhibitors in HL and NHL and biomarkers for predictors of response and outcome.PMC57623914T32CA160040-04T32 CA160040Allen PBChang AFlowers CRSchlafer DfalseInvestigational PD-1 inhibitors in HL and NHL and biomarkers for predictors of response and outcome.<h4>Introduction</h4>Inhibitors against the PD-1/PD-L1 pathway are revolutionizing the treatment and management of malignancies.<h4>Areas covered</h4>We summarize our current understanding of the function of PD-1, its role in immune evasion, the clinical data available that support the use of PD-1 antagonist in Hodgkin and non-Hodgkin lymphomas, and potential predictors of response.<h4>Expert opinion</h4>We anticipate that in the next 10 years, agents that modulate the immune system such as PD-1 antagonists will be increasingly used in favor over traditional cytotoxic chemotherapeutic agents. PD-1 antagonists will be combined with future immunotherapies or used as adjuncts to cellular therapy to boost tumor-specific immune responses.2018-01-01T00:00:00Z2018 Jan2025-04-19T13:06:55.339Z2019-03-26T22:28:31ZS-EPMC57623912922884010.1080/13543784.2018.1416091