{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(1)"],"submitter":["van de Lest NA"],"pubmed_abstract":["<h4>Introduction</h4>Minimal change disease is a common cause of nephrotic syndrome. In general, patients with minimal change disease respond to corticosteroids and have excellent long-term renal survival. However, some patients have less favorable outcome. These patients are often thought to have progressed to focal segmental glomerulosclerosis. We previously reported that a segmental loss of podocyte markers is present before the development of focal segmental glomerulosclerosis in a rat model. Here, we investigated whether loss of podocyte marker nephrin can serve as a biomarker for predicting poor outcome in patients with minimal change disease.<h4>Methods</h4>We obtained 47 kidney biopsy samples from patients diagnosed with minimal change disease and stained sections with periodic aci"],"journal":["Kidney international reports"],"pagination":["168-177"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5762955"],"repository":["biostudies-literature"],"pubmed_title":["Nephrin Loss Can Be Used to Predict Remission and Long-term Renal Outcome in Patients With Minimal Change Disease."],"pmcid":["PMC5762955"],"pubmed_authors":["IJpelaar DHT","Wolterbeek R","Scharpfenecker M","Bruijn JA","Bajema IM","van de Lest NA","Zandbergen M"],"additional_accession":[]},"is_claimable":false,"name":"Nephrin Loss Can Be Used to Predict Remission and Long-term Renal Outcome in Patients With Minimal Change Disease.","description":"<h4>Introduction</h4>Minimal change disease is a common cause of nephrotic syndrome. In general, patients with minimal change disease respond to corticosteroids and have excellent long-term renal survival. However, some patients have less favorable outcome. These patients are often thought to have progressed to focal segmental glomerulosclerosis. We previously reported that a segmental loss of podocyte markers is present before the development of focal segmental glomerulosclerosis in a rat model. Here, we investigated whether loss of podocyte marker nephrin can serve as a biomarker for predicting poor outcome in patients with minimal change disease.<h4>Methods</h4>We obtained 47 kidney biopsy samples from patients diagnosed with minimal change disease and stained sections with periodic aci","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-04T20:43:36.144Z","creation":"2019-03-27T00:14:49Z"},"accession":"S-EPMC5762955","cross_references":{"pubmed":["29340328"],"doi":["10.1016/j.ekir.2017.09.011"]}}