biostudies-literatureUnknown3(1)van de Lest NA<h4>Introduction</h4>Minimal change disease is a common cause of nephrotic syndrome. In general, patients with minimal change disease respond to corticosteroids and have excellent long-term renal survival. However, some patients have less favorable outcome. These patients are often thought to have progressed to focal segmental glomerulosclerosis. We previously reported that a segmental loss of podocyte markers is present before the development of focal segmental glomerulosclerosis in a rat model. Here, we investigated whether loss of podocyte marker nephrin can serve as a biomarker for predicting poor outcome in patients with minimal change disease.<h4>Methods</h4>We obtained 47 kidney biopsy samples from patients diagnosed with minimal change disease and stained sections with periodic aciKidney international reports168-177https://www.ebi.ac.uk/biostudies/studies/S-EPMC5762955biostudies-literatureNephrin Loss Can Be Used to Predict Remission and Long-term Renal Outcome in Patients With Minimal Change Disease.PMC5762955IJpelaar DHTWolterbeek RScharpfenecker MBruijn JABajema IMvan de Lest NAZandbergen MfalseNephrin Loss Can Be Used to Predict Remission and Long-term Renal Outcome in Patients With Minimal Change Disease.<h4>Introduction</h4>Minimal change disease is a common cause of nephrotic syndrome. In general, patients with minimal change disease respond to corticosteroids and have excellent long-term renal survival. However, some patients have less favorable outcome. These patients are often thought to have progressed to focal segmental glomerulosclerosis. We previously reported that a segmental loss of podocyte markers is present before the development of focal segmental glomerulosclerosis in a rat model. Here, we investigated whether loss of podocyte marker nephrin can serve as a biomarker for predicting poor outcome in patients with minimal change disease.<h4>Methods</h4>We obtained 47 kidney biopsy samples from patients diagnosed with minimal change disease and stained sections with periodic aci2018-01-01T00:00:00Z2018 Jan2025-04-04T20:43:36.144Z2019-03-27T00:14:49ZS-EPMC57629552934032810.1016/j.ekir.2017.09.011