{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Allen H"],"pubmed_abstract":["Culturing 3D-expanded human placental-derived adherent stromal cells (ASCs) in the presence of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) transiently upregulated the secretion of numerous anti-proliferative, anti-angiogenic and pro-inflammatory cytokines. In a 3D-spheroid screening assay, conditioned medium from these induced-ASCs inhibited proliferation of cancer cell lines, including triple-negative breast cancer (TNBC) lines. In vitro co-culture studies of induced-ASCs with MDA-MB-231 human breast carcinoma cells, a model representing TNBC, supports a mechanism involving immunomodulation and angiogenesis inhibition. In vivo studies in nude mice showed that intramuscular administration of induced-ASCs halted MDA-MB-231 cell proliferation, and inhibited tumor progres"],"journal":["Scientific reports"],"pagination":["670"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5766494"],"repository":["biostudies-literature"],"pubmed_title":["Human Placental-Derived Adherent Stromal Cells Co-Induced with TNF-α and IFN-γ Inhibit Triple-Negative Breast Cancer in Nude Mouse Xenograft Models."],"pmcid":["PMC5766494"],"pubmed_authors":["Allen H","Aberman Z","Dego-Ashto T","Shraga-Heled N","Fuchs-Telem D","Blumenfeld M","Gilert A","Ofir R"],"additional_accession":[]},"is_claimable":false,"name":"Human Placental-Derived Adherent Stromal Cells Co-Induced with TNF-α and IFN-γ Inhibit Triple-Negative Breast Cancer in Nude Mouse Xenograft Models.","description":"Culturing 3D-expanded human placental-derived adherent stromal cells (ASCs) in the presence of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) transiently upregulated the secretion of numerous anti-proliferative, anti-angiogenic and pro-inflammatory cytokines. In a 3D-spheroid screening assay, conditioned medium from these induced-ASCs inhibited proliferation of cancer cell lines, including triple-negative breast cancer (TNBC) lines. In vitro co-culture studies of induced-ASCs with MDA-MB-231 human breast carcinoma cells, a model representing TNBC, supports a mechanism involving immunomodulation and angiogenesis inhibition. In vivo studies in nude mice showed that intramuscular administration of induced-ASCs halted MDA-MB-231 cell proliferation, and inhibited tumor progres","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-21T16:16:36.173Z","creation":"2019-03-27T00:14:56Z"},"accession":"S-EPMC5766494","cross_references":{"pubmed":["29330447"],"doi":["10.1038/s41598-017-18428-1"]}}