{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Castellani LN"],"funding":["CIHR"],"pagination":["772"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5768692"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Olanzapine is a widely prescribed antipsychotic drug. While effective in reducing psychoses, treatment with olanzapine causes rapid increases in blood glucose. We wanted to determine if a single bout of exercise, immediately prior to treatment, would attenuate the olanzapine-induced rise in blood glucose and if this occurred in an IL-6 dependent manner. We found that exhaustive, but not moderate exercise, immediately prior to treatment, prevented olanzapine-induced hyperglycemia and this occurred in parallel with increases in serum IL-6. To determine if IL-6 was involved in the mechanisms through which exhaustive exercise protected against olanzapine-induced hyperglycemia several additional experiments were completed. Treatment with IL-6 (3 ng/g bw, IP) alone did not protect against olanza"],"journal":["Scientific reports"],"pubmed_title":["Exercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice."],"pmcid":["PMC5768692"],"funding_grant_id":["MOP 130525"],"pubmed_authors":["Bush N","Peppler WT","Miotto PM","Wright DC","Castellani LN"],"additional_accession":[]},"is_claimable":false,"name":"Exercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice.","description":"Olanzapine is a widely prescribed antipsychotic drug. While effective in reducing psychoses, treatment with olanzapine causes rapid increases in blood glucose. We wanted to determine if a single bout of exercise, immediately prior to treatment, would attenuate the olanzapine-induced rise in blood glucose and if this occurred in an IL-6 dependent manner. We found that exhaustive, but not moderate exercise, immediately prior to treatment, prevented olanzapine-induced hyperglycemia and this occurred in parallel with increases in serum IL-6. To determine if IL-6 was involved in the mechanisms through which exhaustive exercise protected against olanzapine-induced hyperglycemia several additional experiments were completed. Treatment with IL-6 (3 ng/g bw, IP) alone did not protect against olanza","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-19T02:03:03.917Z","creation":"2019-03-26T22:58:32Z"},"accession":"S-EPMC5768692","cross_references":{"pubmed":["29335597"],"doi":["10.1038/s41598-018-19260-x"]}}