biostudies-literatureCastellani LNCIHR772https://www.ebi.ac.uk/biostudies/studies/S-EPMC5768692biostudies-literatureUnknown8(1)Olanzapine is a widely prescribed antipsychotic drug. While effective in reducing psychoses, treatment with olanzapine causes rapid increases in blood glucose. We wanted to determine if a single bout of exercise, immediately prior to treatment, would attenuate the olanzapine-induced rise in blood glucose and if this occurred in an IL-6 dependent manner. We found that exhaustive, but not moderate exercise, immediately prior to treatment, prevented olanzapine-induced hyperglycemia and this occurred in parallel with increases in serum IL-6. To determine if IL-6 was involved in the mechanisms through which exhaustive exercise protected against olanzapine-induced hyperglycemia several additional experiments were completed. Treatment with IL-6 (3 ng/g bw, IP) alone did not protect against olanzaScientific reportsExercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice.PMC5768692MOP 130525Bush NPeppler WTMiotto PMWright DCCastellani LNfalseExercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice.Olanzapine is a widely prescribed antipsychotic drug. While effective in reducing psychoses, treatment with olanzapine causes rapid increases in blood glucose. We wanted to determine if a single bout of exercise, immediately prior to treatment, would attenuate the olanzapine-induced rise in blood glucose and if this occurred in an IL-6 dependent manner. We found that exhaustive, but not moderate exercise, immediately prior to treatment, prevented olanzapine-induced hyperglycemia and this occurred in parallel with increases in serum IL-6. To determine if IL-6 was involved in the mechanisms through which exhaustive exercise protected against olanzapine-induced hyperglycemia several additional experiments were completed. Treatment with IL-6 (3 ng/g bw, IP) alone did not protect against olanza2018-01-01T00:00:00Z2018 Jan2025-04-19T02:03:03.917Z2019-03-26T22:58:32ZS-EPMC57686922933559710.1038/s41598-018-19260-x