{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu T"],"funding":["National Institute of Neurological Disorders and Stroke","National Basic Research Program of China","Howard Hughes Medical Institute","National Natural Science Foundation of China","Youth Innovation Promotion Association of the Chinese Academy of Sciences"],"pagination":["4063-4071"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5769588"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["130(23)"],"pubmed_abstract":["Our previous work showed that the cell adhesion molecule SAX-7 forms an elaborate pattern in <i>Caenorhabditis elegans</i> epidermal cells, which instructs PVD dendrite branching. However, the molecular mechanism forming the SAX-7 pattern in the epidermis is not fully understood. Here, we report that the dynein light intermediate chain DLI-1 and the fusogen EFF-1 are required in epidermal cells to pattern SAX-7. While previous reports suggest that these two molecules act cell-autonomously in the PVD, our results show that the disorganized PVD dendritic arbors in these mutants are due to the abnormal SAX-7 localization patterns in epidermal cells. Three lines of evidence support this notion. First, the epidermal SAX-7 pattern was severely affected in <i>dli-1</i> and <i>eff-1</i> mutants. S"],"journal":["Journal of cell science"],"pubmed_title":["Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells."],"pmcid":["PMC5769588"],"funding_grant_id":["2013CB910103","1R01NS082208","31571061, 31771138, 31428009"],"pubmed_authors":["Shen K","Wang XM","Liang X","Zhu T"],"additional_accession":[]},"is_claimable":false,"name":"Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells.","description":"Our previous work showed that the cell adhesion molecule SAX-7 forms an elaborate pattern in <i>Caenorhabditis elegans</i> epidermal cells, which instructs PVD dendrite branching. However, the molecular mechanism forming the SAX-7 pattern in the epidermis is not fully understood. Here, we report that the dynein light intermediate chain DLI-1 and the fusogen EFF-1 are required in epidermal cells to pattern SAX-7. While previous reports suggest that these two molecules act cell-autonomously in the PVD, our results show that the disorganized PVD dendritic arbors in these mutants are due to the abnormal SAX-7 localization patterns in epidermal cells. Three lines of evidence support this notion. First, the epidermal SAX-7 pattern was severely affected in <i>dli-1</i> and <i>eff-1</i> mutants. S","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2025-04-19T02:02:17.301Z","creation":"2019-03-27T00:09:24Z"},"accession":"S-EPMC5769588","cross_references":{"pubmed":["29074578"],"doi":["10.1242/jcs.201699"]}}