biostudies-literatureBasu SNIDDK NIH HHSNHLBI NIH HHSNIMHD NIH HHS788-798https://www.ebi.ac.uk/biostudies/studies/S-EPMC5769867biostudies-literatureUnknown5(10)<h4>Background</h4>In view of substantial mis-estimation of risks of diabetes complications using existing equations, we sought to develop updated Risk Equations for Complications Of type 2 Diabetes (RECODe).<h4>Methods</h4>To develop and validate these risk equations, we used data from the Action to Control Cardiovascular Risk in Diabetes study (ACCORD, n=9635; 2001-09) and validated the equations for microvascular events using data from the Diabetes Prevention Program Outcomes Study (DPPOS, n=1018; 1996-2001), and for cardiovascular events using data from the Action for Health in Diabetes (Look AHEAD, n=4760; 2001-12). Microvascular outcomes were nephropathy, retinopathy, and neuropathy. Cardiovascular outcomes were myocardial infarction, stroke, congestive heart failure, and cardiovascuThe lancet. Diabetes & endocrinologyDevelopment and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials.PMC5769867P30 DK092926DP2 MD010478K23 DK109200P60 DK020572L30 DK103291R01 HL132814K08 HL121056U54 MD010724Yudkin JSSussman JBBerkowitz SAHayward RABasu SfalseDevelopment and validation of Risk Equations for Complications Of type 2 Diabetes (RECODe) using individual participant data from randomised trials.<h4>Background</h4>In view of substantial mis-estimation of risks of diabetes complications using existing equations, we sought to develop updated Risk Equations for Complications Of type 2 Diabetes (RECODe).<h4>Methods</h4>To develop and validate these risk equations, we used data from the Action to Control Cardiovascular Risk in Diabetes study (ACCORD, n=9635; 2001-09) and validated the equations for microvascular events using data from the Diabetes Prevention Program Outcomes Study (DPPOS, n=1018; 1996-2001), and for cardiovascular events using data from the Action for Health in Diabetes (Look AHEAD, n=4760; 2001-12). Microvascular outcomes were nephropathy, retinopathy, and neuropathy. Cardiovascular outcomes were myocardial infarction, stroke, congestive heart failure, and cardiovascu2017-01-01T00:00:00Z2017 Oct2025-04-27T04:18:14.952Z2019-03-27T00:15:04ZS-EPMC57698672880384010.1016/s2213-8587(17)30221-810.1016/S2213-8587(17)30221-8