biostudies-literatureKim DKNational Research Foundation of Korea2https://www.ebi.ac.uk/biostudies/studies/S-EPMC5771139biostudies-literatureUnknown13(1)<h4>Background</h4>Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathological mechanisms underlying AD, developing animal models that completely encompass the main features of AD pathologies is indispensable. Although mouse models that display pathological hallmarks of AD (amyloid plaques, neurofibrillary tangles, or both) have been developed and investigated, a systematic approach for understanding the molecular characteristics of AD mouse models is lacking.<h4>Methods</h4>To elucidate the mechanisms underlying the contribution of amyloid beta (Aβ) and tau in AD pathogenesis, we herein generated a novel animal model of AD, namely the AD-lMolecular neurodegenerationMolecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics.PMC57711392015R1A2A1A050017942014M3C7A10460472015M3C7A10287902011-00307382017M3C9A50315972011-0030740Yang JKim AMook-Jung IPark JKim YKim DKHan DWoo JfalseMolecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics.<h4>Background</h4>Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathological mechanisms underlying AD, developing animal models that completely encompass the main features of AD pathologies is indispensable. Although mouse models that display pathological hallmarks of AD (amyloid plaques, neurofibrillary tangles, or both) have been developed and investigated, a systematic approach for understanding the molecular characteristics of AD mouse models is lacking.<h4>Methods</h4>To elucidate the mechanisms underlying the contribution of amyloid beta (Aβ) and tau in AD pathogenesis, we herein generated a novel animal model of AD, namely the AD-l2018-01-01T00:00:00Z2018 Jan2026-04-29T20:47:34.252Z2019-03-26T22:58:35ZS-EPMC57711392933875410.1186/s13024-017-0234-4