{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mateu-Jimenez M"],"funding":["Fondazione Internazionale Menarini","Instituto de Salud Carlos III","Sociedad Española de Neumología y Cirugía Torácica","Fundació Catalana de Pneumologia"],"pagination":["7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5771157"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["<h4>Background</h4>Chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and epigenetic events underlie lung cancer (LC) development. The study objective was that lung tumor expression levels of specific microRNAs and their downstream biomarkers may be differentially regulated in patients with and without COPD.<h4>Methods</h4>In lung specimens (tumor and non-tumor), microRNAs known to be involved in lung tumorigenesis (miR-21, miR-200b, miR-126, miR-451, miR-210, miR-let7c, miR-30a-30p, miR-155 and miR-let7a, qRT-PCR), DNA methylation, and downstream biomarkers were determined (qRT-PCR and immunoblotting) in 40 patients with LC (prospective study, subdivided into LC-COPD and LC, <i>N</i> = 20/group).<h4>Results</h4>Expression of miR-21, miR-200b, miR-210, and miR-let7c"],"journal":["Clinical epigenetics"],"pubmed_title":["Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions."],"pmcid":["PMC5771157"],"funding_grant_id":["SEPAR 2016","FIS 14/00713 (FEDER)","FIS 11/02029 (FEDER)","CIBER Enfermedades Respiratorias","unrestricted grant from Menarini SA 2014","FUCAP 2016","PT13/0010/0005 (FEDER)"],"pubmed_authors":["Aguilo R","Pijuan L","Mateu-Jimenez M","Rodriguez-Fuster A","Barreiro E","Sanchez-Font A","Curull V","Gea J"],"additional_accession":[]},"is_claimable":false,"name":"Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions.","description":"<h4>Background</h4>Chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and epigenetic events underlie lung cancer (LC) development. The study objective was that lung tumor expression levels of specific microRNAs and their downstream biomarkers may be differentially regulated in patients with and without COPD.<h4>Methods</h4>In lung specimens (tumor and non-tumor), microRNAs known to be involved in lung tumorigenesis (miR-21, miR-200b, miR-126, miR-451, miR-210, miR-let7c, miR-30a-30p, miR-155 and miR-let7a, qRT-PCR), DNA methylation, and downstream biomarkers were determined (qRT-PCR and immunoblotting) in 40 patients with LC (prospective study, subdivided into LC-COPD and LC, <i>N</i> = 20/group).<h4>Results</h4>Expression of miR-21, miR-200b, miR-210, and miR-let7c","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-06-17T07:01:18.784Z","creation":"2026-06-17T03:10:44.753Z"},"accession":"S-EPMC5771157","cross_references":{"pubmed":["29371906"],"doi":["10.1186/s13148-017-0437-0"]}}