biostudies-literatureMuehe AMEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHS324-335https://www.ebi.ac.uk/biostudies/studies/S-EPMC5773418biostudies-literatureUnknown20(2)<h4>Purpose</h4>To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h.<h4>Procedures</h4>In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [¹⁸F]FDG (2-3 MBq/kg). Time needed for patient preparation, PET/MR image acquisition, and data processing was compared before (n = 5) and after (n = 15) time-saving interventions, using a Wilcoxon test. The ferumoxytol-enhanced PET/MR images were compared with clinical sMolecular imaging and biologyHow to Provide Gadolinium-Free PET/MR Cancer Staging of Children and Young Adults in Less than 1 h: the Stanford Approach.PMC5773418R01 HD081123R01 HD081123-01A1Theruvath AJAghighi MMarina NMuehe AMLuna-Fineman SQuon AHoldsworth SJAdvani RRosenberg JLai LWang JDaldrup-Link HEfalseHow to Provide Gadolinium-Free PET/MR Cancer Staging of Children and Young Adults in Less than 1 h: the Stanford Approach.<h4>Purpose</h4>To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h.<h4>Procedures</h4>In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [¹⁸F]FDG (2-3 MBq/kg). Time needed for patient preparation, PET/MR image acquisition, and data processing was compared before (n = 5) and after (n = 15) time-saving interventions, using a Wilcoxon test. The ferumoxytol-enhanced PET/MR images were compared with clinical s2018-01-01T00:00:00Z2018 Apr2025-04-04T20:43:41.958Z2019-08-04T08:21:18ZS-EPMC57734182872160510.1007/s11307-017-1105-7