{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Jin H"],"pubmed_abstract":["Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique \"rolling-up and closure of nanosheet\" mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes. These nanotubes undergo a pH-triggered, reversible contraction-expansion motion. By varying the number of hydrophobic residues of peptoids, we demonstrate tuning of nanotube wall thickness, diameter, and mechanical properties. Atomic force microscopy-based mechanical measurements show peptoid nanotubes are highly stiff (Young's Modulus ~13-17 GPa). We further demonstrate the precise incorporation of functional groups within nanotubes and their applications in water decontamination and cellular adhesion and uptake. These nanotubes provide a robust platform for developing biomimetic materials tailored to specific applications."],"journal":["Nature communications"],"pagination":["270"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5773689"],"repository":["biostudies-literature"],"pubmed_title":["Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids."],"pmcid":["PMC5773689"],"pubmed_authors":["Liao Z","Chen CL","Ding YH","Newcomb CJ","Lin Y","Wang M","Jin H","Li Z","Jian T","Mu P","Tang XQ","Song Y","Wu X","Yan F"],"additional_accession":[]},"is_claimable":false,"name":"Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids.","description":"Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique \"rolling-up and closure of nanosheet\" mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes. These nanotubes undergo a pH-triggered, reversible contraction-expansion motion. By varying the number of hydrophobic residues of peptoids, we demonstrate tuning of nanotube wall thickness, diameter, and mechanical properties. Atomic force microscopy-based mechanical measurements show peptoid nanotubes are highly stiff (Young's Modulus ~13-17 GPa). We further demonstrate the precise incorporation of functional groups within nanotubes and their applications in water decontamination and cellular adhesion and uptake. These nanotubes provide a robust platform for developing biomimetic materials tailored to specific applications.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-04T11:30:56.802Z","creation":"2019-03-26T22:58:21Z"},"accession":"S-EPMC5773689","cross_references":{"pubmed":["29348551"],"doi":["10.1038/s41467-017-02059-1"]}}