{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mohammed BM"],"funding":["British Heart Foundation","NHLBI NIH HHS","National Institutes of Health"],"pagination":["94-105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5776729"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["161"],"pubmed_abstract":["Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to thrombin generation during blood coagulation by proteolytic activation of several coagulation factors, most notably factor IX (FIX). FXI is a homolog of prekallikrein (PK), a component of the plasma kallikrein-kinin system. While sharing structural and functional features with PK, FXI has undergone adaptive changes that allow it to contribute to blood coagulation. Here we review current understanding of the biology and enzymology of FXI, with an emphasis on structural features of the protein as they relate to protease function."],"journal":["Thrombosis research"],"pubmed_title":["An update on factor XI structure and function."],"pmcid":["PMC5776729"],"funding_grant_id":["R35 HL140025","HL58837","PG/09/025/27136","HL81326","R01 HL081326","RG/12/9/29775","R01 HL058837","HL130018","R01 HL130018"],"pubmed_authors":["Gailani D","Mohammed BM","Li C","Matafonov A","Cheng Q","Ivanov I","Verhamme IM","Sun MF","Sun D","Emsley J","Dickeson SK"],"additional_accession":[]},"is_claimable":false,"name":"An update on factor XI structure and function.","description":"Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to thrombin generation during blood coagulation by proteolytic activation of several coagulation factors, most notably factor IX (FIX). FXI is a homolog of prekallikrein (PK), a component of the plasma kallikrein-kinin system. While sharing structural and functional features with PK, FXI has undergone adaptive changes that allow it to contribute to blood coagulation. Here we review current understanding of the biology and enzymology of FXI, with an emphasis on structural features of the protein as they relate to protease function.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-27T02:31:25.304Z","creation":"2019-03-26T22:28:32Z"},"accession":"S-EPMC5776729","cross_references":{"pubmed":["29223926"],"doi":["10.1016/j.thromres.2017.10.008"]}}