{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muratore CR"],"funding":["Rick and Nancy Moskovitz","NIA NIH HHS","Brigham Research Institute","BrightFocus Foundation","NIH"],"pagination":["1868-1884"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5785690"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(6)"],"pubmed_abstract":["Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ, which plays a central role in AD pathogenesis, is generated throughout the brain, yet some regions outside of the limbic and cerebral cortices are relatively spared from Aβ plaque deposition and synapse loss. Here, we examine neurons derived from iPSCs of patients harboring an amyloid precursor protein mutation to quantify AD-relevant phenotypes following directed differentiation to rostral fates of the brain (vulnerable) and caudal fates (relatively spared) in AD. We find that both the generation of Aβ and the responsiveness of TAU to Aβ are affected by neuro"],"journal":["Stem cell reports"],"pubmed_title":["Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability."],"pmcid":["PMC5785690"],"funding_grant_id":["AG049864","R21 AG056011","AG056011","P30 AG010161","RF1 AG006173","R33 AG049864","R01 AG017917","T32AG000222","T32 AG000222"],"pubmed_authors":["Zhou M","Shin T","Taylor WM","Pearse RV","Rice HC","Lagomarsino VN","Bennett DA","Zhou C","Fernandez MA","Negri JM","Love JC","Selkoe DJ","Srikanth P","Callahan DG","He A","Young-Pearse TL","Muratore CR","Liao M","Noggle S"],"additional_accession":[]},"is_claimable":false,"name":"Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.","description":"Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ, which plays a central role in AD pathogenesis, is generated throughout the brain, yet some regions outside of the limbic and cerebral cortices are relatively spared from Aβ plaque deposition and synapse loss. Here, we examine neurons derived from iPSCs of patients harboring an amyloid precursor protein mutation to quantify AD-relevant phenotypes following directed differentiation to rostral fates of the brain (vulnerable) and caudal fates (relatively spared) in AD. We find that both the generation of Aβ and the responsiveness of TAU to Aβ are affected by neuro","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2026-05-06T03:02:10.554Z","creation":"2019-03-26T22:59:00Z"},"accession":"S-EPMC5785690","cross_references":{"pubmed":["29153990"],"doi":["10.1016/j.stemcr.2017.10.015"]}}