biostudies-literatureBass ARAbbott LaboratoriesWeill Cornell Clinical &amp; Translational Science CenterPfizer Foundation67-76https://www.ebi.ac.uk/biostudies/studies/S-EPMC5786589biostudies-literatureUnknown14(1)<h4>Background</h4>Orthopedic patients are at risk for adverse postoperative cardiovascular outcomes.<h4>Questions/purposes</h4>This pilot randomized controlled trial (RCT) of atorvastatin vs. placebo in orthopedic surgery patients was performed in order to assess: (1) the prevalence of perioperative myocardial injury; (2) the effect of atorvastatin on perioperative inflammation; and (3) the feasibility of performing a large RCT of statin therapy in orthopedic patients.<h4>Methods</h4>Hip fracture (hip Fx) and total hip and knee replacement (THR and TKR) patients were randomized 1:1 to atorvastatin 40 mg daily vs. placebo, starting preoperatively and continuing until postoperative day (POD) 45. High-sensitivity cardiac troponin I (hs-cTnI), high-sensitivity C-reactive protein (hs-CRP), andHSS journal : the musculoskeletal journal of Hospital for Special SurgeryPostoperative Myocardial Injury and Inflammation Is Not Blunted by a Trial of Atorvastatin in Orthopedic Surgery Patients.PMC5786589UL1TR000457-06Valle AGDEby CMerritt KStevens SMMoskowitz GFlores ESzymonifka JDRondina MTBogardus MGage BFScott MGBass ARWoller SCfalsePostoperative Myocardial Injury and Inflammation Is Not Blunted by a Trial of Atorvastatin in Orthopedic Surgery Patients.<h4>Background</h4>Orthopedic patients are at risk for adverse postoperative cardiovascular outcomes.<h4>Questions/purposes</h4>This pilot randomized controlled trial (RCT) of atorvastatin vs. placebo in orthopedic surgery patients was performed in order to assess: (1) the prevalence of perioperative myocardial injury; (2) the effect of atorvastatin on perioperative inflammation; and (3) the feasibility of performing a large RCT of statin therapy in orthopedic patients.<h4>Methods</h4>Hip fracture (hip Fx) and total hip and knee replacement (THR and TKR) patients were randomized 1:1 to atorvastatin 40 mg daily vs. placebo, starting preoperatively and continuing until postoperative day (POD) 45. High-sensitivity cardiac troponin I (hs-cTnI), high-sensitivity C-reactive protein (hs-CRP), and2018-01-01T00:00:00Z2018 Feb2026-05-05T04:36:09.5Z2019-03-26T22:50:03ZS-EPMC57865892939899810.1007/s11420-017-9577-1