{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["103(2)"],"submitter":["Schneider E"],"funding":["CIHR"],"pubmed_abstract":["Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR-155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells <i>in vivo</i> However, in the absence or following the removal of miR-155, leukemia onset and progression were unaffected. Although miR-155 accelerated growth and homing in addition to impairing differentiation, our data underscore the pathophysiological relevance of miR-155 as an accelerator rather than a driver of leukemogenes"],"journal":["Haematologica"],"pagination":["246-255"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5792269"],"repository":["biostudies-literature"],"pubmed_title":["Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia."],"pmcid":["PMC5792269"],"pubmed_authors":["Heuser M","Xiang P","Bullinger L","Ashouri A","Arabanian L","Dohner K","Rouhi A","Schneider E","Rohner L","Buske C","Hirst M","Miller C","Pochert N","Palmqvist L","Staffas A","Wei SY","Dohner H","Hansen CL","Humphries RK","Ruschmann J","Petriv OI","Krowiorz K","Fogelstrand L","Kuchenbauer F","Heravi-Moussavi A","Malmberg ED"],"additional_accession":[]},"is_claimable":false,"name":"Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.","description":"Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR-155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells <i>in vivo</i> However, in the absence or following the removal of miR-155, leukemia onset and progression were unaffected. Although miR-155 accelerated growth and homing in addition to impairing differentiation, our data underscore the pathophysiological relevance of miR-155 as an accelerator rather than a driver of leukemogenes","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2026-04-15T21:15:17.928Z","creation":"2019-06-06T18:51:59Z"},"accession":"S-EPMC5792269","cross_references":{"pubmed":["29217774"],"doi":["10.3324/haematol.2017.177485"]}}