biostudies-literatureUnknown103(2)Schneider ECIHRMicro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR-155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells <i>in vivo</i> However, in the absence or following the removal of miR-155, leukemia onset and progression were unaffected. Although miR-155 accelerated growth and homing in addition to impairing differentiation, our data underscore the pathophysiological relevance of miR-155 as an accelerator rather than a driver of leukemogenesHaematologica246-255https://www.ebi.ac.uk/biostudies/studies/S-EPMC5792269biostudies-literatureMicro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.PMC5792269Heuser MXiang PBullinger LAshouri AArabanian LDohner KRouhi ASchneider ERohner LBuske CHirst MMiller CPochert NPalmqvist LStaffas AWei SYDohner HHansen CLHumphries RKRuschmann JPetriv OIKrowiorz KFogelstrand LKuchenbauer FHeravi-Moussavi AMalmberg EDfalseMicro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR-155 accelerated the formation of acute myeloid leukemia in Hoxa9 as well as in Hoxa9/Meis1 cells <i>in vivo</i> However, in the absence or following the removal of miR-155, leukemia onset and progression were unaffected. Although miR-155 accelerated growth and homing in addition to impairing differentiation, our data underscore the pathophysiological relevance of miR-155 as an accelerator rather than a driver of leukemogenes2018-01-01T00:00:00Z2018 Feb2026-04-15T21:15:17.928Z2019-06-06T18:51:59ZS-EPMC57922692921777410.3324/haematol.2017.177485