{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(1)"],"submitter":["Oliveira MP"],"pubmed_abstract":["In a proteomics approach conducted with Leishmania amazonensis, parasite proteins showed either an increase or a decrease in their expression content during extensive in vitro cultivation, and were related to the survival and the infectivity of the parasites, respectively. In the current study, a computational screening was performed to predict virulence factors among these molecules. Three proteins were selected, one of which presented no homology to human proteins. This candidate, namely small myristoylated protein-3 (SMP-3), was cloned, and its recombinant version (rSMP-3) was used to stimulate peripheral blood mononuclear cells (PBMCs) from healthy subjects living in an endemic area of leishmaniasis and from visceral leishmaniasis patients. Results showed high interferon-γ (IFN-γ) prod"],"journal":["International journal of molecular sciences"],"pagination":["E129"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5796078"],"repository":["biostudies-literature"],"pubmed_title":["Small Myristoylated Protein-3, Identified as a Potential Virulence Factor in Leishmania amazonensis, Proves to be a Protective Antigen against Visceral Leishmaniasis."],"pmcid":["PMC5796078"],"pubmed_authors":["Lage DP","Teixeira AL","Coelho EAF","Oliveira MP","Santos TTO","Chavez-Fumagalli MA","Martins VT","Costa LE","Ribeiro PAF","Machado-de-Avila RA","Ramos FF","Salles BCS","Dias DS","Schneider MS"],"additional_accession":[]},"is_claimable":false,"name":"Small Myristoylated Protein-3, Identified as a Potential Virulence Factor in Leishmania amazonensis, Proves to be a Protective Antigen against Visceral Leishmaniasis.","description":"In a proteomics approach conducted with Leishmania amazonensis, parasite proteins showed either an increase or a decrease in their expression content during extensive in vitro cultivation, and were related to the survival and the infectivity of the parasites, respectively. In the current study, a computational screening was performed to predict virulence factors among these molecules. Three proteins were selected, one of which presented no homology to human proteins. This candidate, namely small myristoylated protein-3 (SMP-3), was cloned, and its recombinant version (rSMP-3) was used to stimulate peripheral blood mononuclear cells (PBMCs) from healthy subjects living in an endemic area of leishmaniasis and from visceral leishmaniasis patients. Results showed high interferon-γ (IFN-γ) prod","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-06-01T03:28:06.167Z","creation":"2025-06-01T03:28:06.167Z"},"accession":"S-EPMC5796078","cross_references":{"pubmed":["29301342"],"doi":["10.3390/ijms19010129"]}}