biostudies-literatureZhang XNCATS NIH HHSNIA NIH HHSNHLBI NIH HHS405-412https://www.ebi.ac.uk/biostudies/studies/S-EPMC5798248biostudies-literatureUnknown236<h4>Background</h4>Angiotensin-(1-7) [Ang-(1-7)] exhibits cardiovascular effects opposite those of angiotensin II (Ang II), thus providing protection against heart disease. However, how Ang-(1-7) imparts cardioprotection is unclear, and its direct cardiac effects are controversial. Whether heart failure (HF) alters cardiac contractile responses to Ang-(1-7) remains undetermined. We tested the hypothesis that in HF, Ang-(1-7) may produce positive modulation on [Ca²⁺]_i regulation, enhancing left ventricular (LV) and myocyte contraction and relaxation via Ang-(1-7) Mas receptor coupled with nitric oxide (NO)/bradykinin (BK)-mediated mechanism.<h4>Methods and results</h4>We measured LV contractility changes after Ang-(1-7) (650ng/kg, iv) and compared myocyte functional anInternational journal of cardiologyCellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure.PMC5798248R01 AG049770R01 HL074318UL1 TR001420P01 HL051952Kitzman DWCheng HJZhou PFerrario CMLi WMZhang XCheng CPfalseCellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure.<h4>Background</h4>Angiotensin-(1-7) [Ang-(1-7)] exhibits cardiovascular effects opposite those of angiotensin II (Ang II), thus providing protection against heart disease. However, how Ang-(1-7) imparts cardioprotection is unclear, and its direct cardiac effects are controversial. Whether heart failure (HF) alters cardiac contractile responses to Ang-(1-7) remains undetermined. We tested the hypothesis that in HF, Ang-(1-7) may produce positive modulation on [Ca²⁺]_i regulation, enhancing left ventricular (LV) and myocyte contraction and relaxation via Ang-(1-7) Mas receptor coupled with nitric oxide (NO)/bradykinin (BK)-mediated mechanism.<h4>Methods and results</h4>We measured LV contractility changes after Ang-(1-7) (650ng/kg, iv) and compared myocyte functional an2017-01-01T00:00:00Z2017 Jun2025-04-19T13:14:53.108Z2019-03-26T23:39:00ZS-EPMC57982482809604710.1016/j.ijcard.2017.01.071