{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Satterfield BC"],"funding":["NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health","Sleep Research Society Foundation","Office of the Assistant Secretary for Health"],"pagination":["179-186"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5801055"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99"],"pubmed_abstract":["Adaptive decision making is profoundly impaired by total sleep deprivation (TSD). This suggests that TSD impacts fronto-striatal pathways involved in cognitive control, where dopamine is a key neuromodulator. In the prefrontal cortex (PFC), dopamine is catabolized by the enzyme catechol-O-methyltransferase (COMT). A functional polymorphism (Val158Met) influences COMT's enzymatic activity, resulting in markedly different levels of prefrontal dopamine. We investigated the effect of this polymorphism on adaptive decision making during TSD. Sixty-six healthy young adults participated in one of two in-laboratory studies. After a baseline day, subjects were randomized to either a TSD group (n = 32) with 38 h or 62 h of extended wakefulness or a well-rested control group (n = 34) with 10 h nightt"],"journal":["Cortex; a journal devoted to the study of the nervous system and behavior"],"pubmed_title":["Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation."],"pmcid":["PMC5801055"],"funding_grant_id":["R01HL105768","DTFAAC-11-A-00003","R01 HL105768","R21 CA167691","R21CA167691"],"pubmed_authors":["Wisor JP","Satterfield BC","Van Dongen HPA","Hinson JM","Schmidt MA","Whitney P"],"additional_accession":[]},"is_claimable":false,"name":"Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation.","description":"Adaptive decision making is profoundly impaired by total sleep deprivation (TSD). This suggests that TSD impacts fronto-striatal pathways involved in cognitive control, where dopamine is a key neuromodulator. In the prefrontal cortex (PFC), dopamine is catabolized by the enzyme catechol-O-methyltransferase (COMT). A functional polymorphism (Val158Met) influences COMT's enzymatic activity, resulting in markedly different levels of prefrontal dopamine. We investigated the effect of this polymorphism on adaptive decision making during TSD. Sixty-six healthy young adults participated in one of two in-laboratory studies. After a baseline day, subjects were randomized to either a TSD group (n = 32) with 38 h or 62 h of extended wakefulness or a well-rested control group (n = 34) with 10 h nightt","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2025-04-05T12:16:38.895Z","creation":"2019-03-26T22:46:45Z"},"accession":"S-EPMC5801055","cross_references":{"pubmed":["29248857"],"doi":["10.1016/j.cortex.2017.11.012"]}}