biostudies-literatureBadgujar JRUniversity Grants Commission93-99https://www.ebi.ac.uk/biostudies/studies/S-EPMC5801178biostudies-literatureUnknown58(1)A series of new sulfonamides have been synthesized from Ampyrone with different benzene sulfonyl chlorides to yield the N-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) benzenesulfonamides (4a-e). All synthesized compounds were characterized on the basis of FTIR, 1H NMR, and 13C NMR, and also by the aid of mass spectral data. Further, all synthesized compounds have studied for their in vitro antimicrobial activities against selected bacterial as well as fungal strains by the agar well diffusion method. Free radical scavenging activity has been investigated by using DPPH method. Among all the synthesized compounds, 4b, 4d, and 4e exhibited significant antimicrobial and antioxidant activities.Indian journal of microbiologySynthesis, Antimicrobial and Antioxidant Activity of Pyrazole Based Sulfonamide Derivatives.PMC5801178dated 13th March2015F.25-1/2014-15(BSR/7-136/2007(BSR)More DHBadgujar JRMeshram JSfalseSynthesis, Antimicrobial and Antioxidant Activity of Pyrazole Based Sulfonamide Derivatives.A series of new sulfonamides have been synthesized from Ampyrone with different benzene sulfonyl chlorides to yield the N-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) benzenesulfonamides (4a-e). All synthesized compounds were characterized on the basis of FTIR, 1H NMR, and 13C NMR, and also by the aid of mass spectral data. Further, all synthesized compounds have studied for their in vitro antimicrobial activities against selected bacterial as well as fungal strains by the agar well diffusion method. Free radical scavenging activity has been investigated by using DPPH method. Among all the synthesized compounds, 4b, 4d, and 4e exhibited significant antimicrobial and antioxidant activities.2018-01-01T00:00:00Z2018 Mar2025-04-05T15:12:30.994Z2019-08-04T07:05:45ZS-EPMC58011782943440210.1007/s12088-017-0689-6