{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Freudenberg K"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","Zentrum für Regenerative Therapien Dresden"],"pagination":["125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5801288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Under physiological conditions, CD4+ regulatory T (Treg) cells expressing the transcription factor Foxp3 are generated in the thymus [thymus-derived Foxp3+ Treg (tTregs) cells] and extrathymically at peripheral sites [peripherally induced Foxp3+ Treg (pTreg) cell], and both developmental subsets play non-redundant roles in maintaining self-tolerance throughout life. In addition, a variety of experimental in vitro and in vivo modalities can extrathymically elicit a Foxp3+ Treg cell phenotype in peripheral CD4+Foxp3- T cells, which has attracted much interest as an approach toward cell-based therapy in clinical settings of undesired immune responses. A particularly notable example is the in vitro induction of Foxp3 expression and Treg cell activity (iTreg cells) in initially naive CD4+Foxp3-"],"journal":["Frontiers in immunology"],"pubmed_title":["Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation."],"pmcid":["PMC5801288"],"funding_grant_id":["SPP1468, GA1576/1-2","FZT 111","FKZ 01GI0805-07, FKZ01GI0924"],"pubmed_authors":["Dohnke S","Kretschmer K","Garbe AI","Schallenberg S","Lindner N","Freudenberg K"],"additional_accession":[]},"is_claimable":false,"name":"Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation.","description":"Under physiological conditions, CD4+ regulatory T (Treg) cells expressing the transcription factor Foxp3 are generated in the thymus [thymus-derived Foxp3+ Treg (tTregs) cells] and extrathymically at peripheral sites [peripherally induced Foxp3+ Treg (pTreg) cell], and both developmental subsets play non-redundant roles in maintaining self-tolerance throughout life. In addition, a variety of experimental in vitro and in vivo modalities can extrathymically elicit a Foxp3+ Treg cell phenotype in peripheral CD4+Foxp3- T cells, which has attracted much interest as an approach toward cell-based therapy in clinical settings of undesired immune responses. A particularly notable example is the in vitro induction of Foxp3 expression and Treg cell activity (iTreg cells) in initially naive CD4+Foxp3-","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-05T15:12:11.256Z","creation":"2019-03-26T23:03:07Z"},"accession":"S-EPMC5801288","cross_references":{"pubmed":["29456534"],"doi":["10.3389/fimmu.2018.00125"]}}