{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Kong C"],"pubmed_abstract":["Staphylococcus aureus is a major cause of nosocomial infections and secretes a diverse spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic-resistant S. aureus highlights the need for alternative forms of therapeutics other than conventional antibiotics. One route to meet this need is screening small molecule derivatives for potential anti-infective activity. Using a previously optimized C. elegans - S. aureus small molecule screen, we identified a benzimidazole derivative, UM-C162, which rescued nematodes from a S. aureus infection. UM-C162 prevented the formation of biofilm in a dose-dependent manner without interfering with bacterial viability. To examine the effect of UM-C162 on the expression of S. aureus virulence genes, a genome-wide transcriptome"],"journal":["Scientific reports"],"pagination":["2758"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5807447"],"repository":["biostudies-literature"],"pubmed_title":["Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162."],"pmcid":["PMC5807447"],"pubmed_authors":["Thomas N","Abd Rahman N","Nathan S","Chee CF","Richter K","Kong C"],"additional_accession":[]},"is_claimable":false,"name":"Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162.","description":"Staphylococcus aureus is a major cause of nosocomial infections and secretes a diverse spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic-resistant S. aureus highlights the need for alternative forms of therapeutics other than conventional antibiotics. One route to meet this need is screening small molecule derivatives for potential anti-infective activity. Using a previously optimized C. elegans - S. aureus small molecule screen, we identified a benzimidazole derivative, UM-C162, which rescued nematodes from a S. aureus infection. UM-C162 prevented the formation of biofilm in a dose-dependent manner without interfering with bacterial viability. To examine the effect of UM-C162 on the expression of S. aureus virulence genes, a genome-wide transcriptome","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2026-05-04T09:33:47.834Z","creation":"2019-03-26T23:02:12Z"},"accession":"S-EPMC5807447","cross_references":{"pubmed":["29426873"],"doi":["10.1038/s41598-018-21141-2"]}}