biostudies-literatureUnknown8(1)Kong CStaphylococcus aureus is a major cause of nosocomial infections and secretes a diverse spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic-resistant S. aureus highlights the need for alternative forms of therapeutics other than conventional antibiotics. One route to meet this need is screening small molecule derivatives for potential anti-infective activity. Using a previously optimized C. elegans - S. aureus small molecule screen, we identified a benzimidazole derivative, UM-C162, which rescued nematodes from a S. aureus infection. UM-C162 prevented the formation of biofilm in a dose-dependent manner without interfering with bacterial viability. To examine the effect of UM-C162 on the expression of S. aureus virulence genes, a genome-wide transcriptomeScientific reports2758https://www.ebi.ac.uk/biostudies/studies/S-EPMC5807447biostudies-literatureSuppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162.PMC5807447Thomas NAbd Rahman NNathan SChee CFRichter KKong CfalseSuppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162.Staphylococcus aureus is a major cause of nosocomial infections and secretes a diverse spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic-resistant S. aureus highlights the need for alternative forms of therapeutics other than conventional antibiotics. One route to meet this need is screening small molecule derivatives for potential anti-infective activity. Using a previously optimized C. elegans - S. aureus small molecule screen, we identified a benzimidazole derivative, UM-C162, which rescued nematodes from a S. aureus infection. UM-C162 prevented the formation of biofilm in a dose-dependent manner without interfering with bacterial viability. To examine the effect of UM-C162 on the expression of S. aureus virulence genes, a genome-wide transcriptome2018-01-01T00:00:00Z2018 Feb2026-05-04T09:33:47.834Z2019-03-26T23:02:12ZS-EPMC58074472942687310.1038/s41598-018-21141-2