{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["80(4)"],"submitter":["Walicke P"],"pubmed_abstract":["This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice. Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new \"science of practice.\""],"journal":["Neurosurgery"],"pagination":["505-514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5808147"],"repository":["biostudies-literature"],"pubmed_title":["Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report."],"pmcid":["PMC5808147"],"pubmed_authors":["Walicke P","Chiocca EA","Little R","Barker FG","Wisniewski S","Jehi L","Workshop Participants","Koroshetz W","Valadka A","Rubin D","Harbaugh R","Abosch A","Ghogawala Z","Kestle J","Asher A"],"additional_accession":[]},"is_claimable":false,"name":"Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report.","description":"This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice. Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new \"science of practice.\"","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2021-02-20T09:06:46Z","creation":"2019-06-06T18:56:38Z"},"accession":"S-EPMC5808147","cross_references":{"pubmed":["28362926"],"doi":["10.1093/neuros/nyw133"]}}