{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Lin J"],"pubmed_abstract":["<h4>Introduction</h4>The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR).<h4>Materials and methods</h4>This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-tocopheryl polyethylene glycol 1000 succinate. This polymer could induce the elevation of reactive oxygen species (ROS) levels, ultimately resulting in cytotoxicity. Moreover, the redox-responsive mixed micelles, F127-folate (FA)/FSST/P123 (FFSSTP), based on FSST, Pluronic F127-FA, and Pluronic P123, were prepared to load paclitaxel (PTX).<h4>Results</h4>The in vitro release study demonstra"],"journal":["International journal of nanomedicine"],"pagination":["805-830"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5808690"],"repository":["biostudies-literature"],"pubmed_title":["Redox-responsive F127-folate/F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate/P123 mixed micelles loaded with paclitaxel for the reversal of multidrug resistance in tumors."],"pmcid":["PMC5808690"],"pubmed_authors":["Fu S","Zhao C","Han L","Lu X","Lin J","Liu C","Yang C"],"additional_accession":[]},"is_claimable":false,"name":"Redox-responsive F127-folate/F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate/P123 mixed micelles loaded with paclitaxel for the reversal of multidrug resistance in tumors.","description":"<h4>Introduction</h4>The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR).<h4>Materials and methods</h4>This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-tocopheryl polyethylene glycol 1000 succinate. This polymer could induce the elevation of reactive oxygen species (ROS) levels, ultimately resulting in cytotoxicity. Moreover, the redox-responsive mixed micelles, F127-folate (FA)/FSST/P123 (FFSSTP), based on FSST, Pluronic F127-FA, and Pluronic P123, were prepared to load paclitaxel (PTX).<h4>Results</h4>The in vitro release study demonstra","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-04T14:48:51.575Z","creation":"2019-03-26T23:02:57Z"},"accession":"S-EPMC5808690","cross_references":{"pubmed":["29445276"],"doi":["10.2147/IJN.S152395"]}}