{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(2)"],"submitter":["Sun S"],"pubmed_abstract":["Current multiplexed analysis methods suffer from either slow reaction kinetics (planar arrays) or complicated encoding/decoding procedures (suspension arrays). We report herein a multiplexed DNA detection strategy that addresses these issues, based on positional encoding/decoding with self-assembled DNA nanostructures. The strategy enables the acquisition of high-resolution, consistent, and quantitative assay results in a single round of a transmission electron microscopy imaging operation. Applications in polymerase chain reaction-free settings and assays of other structurally distinct targets can be anticipated through the implementation of the strategy with miniaturized femtoliter/attoliter dispensing technology and readily accessible DNA conjugate structures."],"journal":["Chemical science"],"pagination":["930-934"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5811145"],"repository":["biostudies-literature"],"pubmed_title":["Multiplexed DNA detection based on positional encoding/decoding with self-assembled DNA nanostructures."],"pmcid":["PMC5811145"],"pubmed_authors":["Zhang F","Zhu J","Sun S","Yao H"],"additional_accession":[]},"is_claimable":false,"name":"Multiplexed DNA detection based on positional encoding/decoding with self-assembled DNA nanostructures.","description":"Current multiplexed analysis methods suffer from either slow reaction kinetics (planar arrays) or complicated encoding/decoding procedures (suspension arrays). We report herein a multiplexed DNA detection strategy that addresses these issues, based on positional encoding/decoding with self-assembled DNA nanostructures. The strategy enables the acquisition of high-resolution, consistent, and quantitative assay results in a single round of a transmission electron microscopy imaging operation. Applications in polymerase chain reaction-free settings and assays of other structurally distinct targets can be anticipated through the implementation of the strategy with miniaturized femtoliter/attoliter dispensing technology and readily accessible DNA conjugate structures.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Feb","modification":"2025-04-04T19:45:37.29Z","creation":"2019-03-26T23:22:33Z"},"accession":"S-EPMC5811145","cross_references":{"pubmed":["29560179"],"doi":["10.1039/c4sc02696a"]}}