{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ilyas SI"],"funding":["NIDDK NIH HHS"],"pagination":["5892-5905"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5814182"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(5)"],"pubmed_abstract":["Deregulated Hippo pathway signaling is associated with aberrant activation of the downstream effector yes-associated protein (YAP), an emerging key oncogenic mediator in cholangiocarcinoma (CCA). In our prior work, we have demonstrated that biliary transduction of YAP along with Akt as a permissive factor induces CCA in mice. To further delineate the mechanisms associated with YAP-associated biliary oncogenesis, we have established seven malignant murine cell lines from our YAP-driven murine CCA model. These cells express the CCA markers SRY (Sex Determining Region Y)-Box 9 (SOX9), cytokeratin (CK)-7 and 19 but lack hepatocyte nuclear factor 4 alpha and alpha-smooth muscle actin, markers of hepatocellular carcinoma and cancer-associated fibroblasts, respectively. Notably, the murine CCA ce"],"journal":["Oncotarget"],"pubmed_title":["YAP-associated chromosomal instability and cholangiocarcinoma in mice."],"pmcid":["PMC5814182"],"funding_grant_id":["R56 DK059427","P30 DK084567","R01 DK059427"],"pubmed_authors":["Ilyas SI","Smoot RL","Gores GJ","Hirsova P","Bronk SF","Krishnan A","Fischbach SR","Vasmatzis G","Dhanasekaran R","Smadbeck JB"],"additional_accession":[]},"is_claimable":false,"name":"YAP-associated chromosomal instability and cholangiocarcinoma in mice.","description":"Deregulated Hippo pathway signaling is associated with aberrant activation of the downstream effector yes-associated protein (YAP), an emerging key oncogenic mediator in cholangiocarcinoma (CCA). In our prior work, we have demonstrated that biliary transduction of YAP along with Akt as a permissive factor induces CCA in mice. To further delineate the mechanisms associated with YAP-associated biliary oncogenesis, we have established seven malignant murine cell lines from our YAP-driven murine CCA model. These cells express the CCA markers SRY (Sex Determining Region Y)-Box 9 (SOX9), cytokeratin (CK)-7 and 19 but lack hepatocyte nuclear factor 4 alpha and alpha-smooth muscle actin, markers of hepatocellular carcinoma and cancer-associated fibroblasts, respectively. Notably, the murine CCA ce","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-04-28T23:07:36.438Z","creation":"2019-03-26T23:03:57Z"},"accession":"S-EPMC5814182","cross_references":{"pubmed":["29464042"],"doi":["10.18632/oncotarget.23638"]}}