{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(5)"],"submitter":["Thakur C"],"pubmed_abstract":["Identifying metastatic tumor growth at an early stage has been one of the biggest challenges in the treatment of lung cancer. By genetic lineage tracing approach in a conditional model of Non-Small Cell Lung Cancer (NSCLC) in mice, we demonstrate that cystic lesions represent an early stage of metastatic invasion. We generated a mouse model for NSCLC which incorporated a heritable DsRed fluorescent tag driven by the ubiquitous CAG promoter in the alveolar type II cells of the lung. We found early cystic lesions in a secondary organ (liver) that lacked the expression of <i>bona fide</i> lung makers namely Scgb1a1 and surfactant protein C Sftpc and were DsRed positive hence identifying lung as their source of origin. This demonstrates the significant potential of alveolar type II cells in or"],"journal":["Oncotarget"],"pagination":["6518-6535"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5814229"],"repository":["biostudies-literature"],"pubmed_title":["Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer."],"pmcid":["PMC5814229"],"pubmed_authors":["Thakur C","Rudel T","Rapp UR"],"additional_accession":[]},"is_claimable":false,"name":"Cysts mark the early stage of metastatic tumor development in non-small cell lung cancer.","description":"Identifying metastatic tumor growth at an early stage has been one of the biggest challenges in the treatment of lung cancer. By genetic lineage tracing approach in a conditional model of Non-Small Cell Lung Cancer (NSCLC) in mice, we demonstrate that cystic lesions represent an early stage of metastatic invasion. We generated a mouse model for NSCLC which incorporated a heritable DsRed fluorescent tag driven by the ubiquitous CAG promoter in the alveolar type II cells of the lung. We found early cystic lesions in a secondary organ (liver) that lacked the expression of <i>bona fide</i> lung makers namely Scgb1a1 and surfactant protein C Sftpc and were DsRed positive hence identifying lung as their source of origin. This demonstrates the significant potential of alveolar type II cells in or","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-21T14:32:20.726Z","creation":"2019-03-26T23:03:58Z"},"accession":"S-EPMC5814229","cross_references":{"pubmed":["29464089"],"doi":["10.18632/oncotarget.23785"]}}