biostudies-literaturePuvvada KCNIBIB NIH HHSNIDA NIH HHSNIMH NIH HHSNIDCD NIH HHSNational Institutes of Health378-387https://www.ebi.ac.uk/biostudies/studies/S-EPMC5814801biostudies-literatureUnknown44(2)<h4>Background</h4>Delta band (1-4 Hz) neuronal responses support the precision and stability of auditory processing, and a deficit in delta band synchrony may be relevant to auditory domain symptoms in schizophrenia patients.<h4>Methods</h4>Delta band synchronization elicited by a 2.5 Hz auditory steady state response (ASSR) paradigm, along with those from theta (5 Hz), alpha (10 Hz), beta (20 Hz), gamma (40 Hz), and high gamma (80 Hz) frequency ASSR, were compared in 128 patients with schizophrenia, 108 healthy controls, and 55 first-degree relatives (FDR) of patients.<h4>Results</h4>Delta band synchronization was significantly impaired in patients compared with controls (F = 18.3, P < .001). There was a significant 2.5 Hz by 40 Hz ASSR interaction (P = .023), arising from a greater reduSchizophrenia bulletinDelta Vs Gamma Auditory Steady State Synchrony in Schizophrenia.PMC5814801U01 MH108148R01MH085646, U01MH108148, P50MH103222 Project 3, R01DA027680 to L.E.H.R01DC014085 to J.Z.S.R01 MH085646R01 MH112180R01 EB015611P50 MH103222R01 DA027680R01 DC014085Hong LESummerfelt AKrishna NSimon JZPuvvada KCDu XRowland LMKochunov PfalseDelta Vs Gamma Auditory Steady State Synchrony in Schizophrenia.<h4>Background</h4>Delta band (1-4 Hz) neuronal responses support the precision and stability of auditory processing, and a deficit in delta band synchrony may be relevant to auditory domain symptoms in schizophrenia patients.<h4>Methods</h4>Delta band synchronization elicited by a 2.5 Hz auditory steady state response (ASSR) paradigm, along with those from theta (5 Hz), alpha (10 Hz), beta (20 Hz), gamma (40 Hz), and high gamma (80 Hz) frequency ASSR, were compared in 128 patients with schizophrenia, 108 healthy controls, and 55 first-degree relatives (FDR) of patients.<h4>Results</h4>Delta band synchronization was significantly impaired in patients compared with controls (F = 18.3, P < .001). There was a significant 2.5 Hz by 40 Hz ASSR interaction (P = .023), arising from a greater redu2018-01-01T00:00:00Z2018 Feb2025-04-21T20:35:12.296Z2019-03-26T22:54:13ZS-EPMC58148012903643010.1093/schbul/sbx078