{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["97(5)"],"submitter":["Pratt-Riccio LR"],"pubmed_abstract":["Peptide vaccine strategies using <i>Plasmodium</i>-derived antigens have emerged as an attractive approach against malaria. However, relatively few studies have been conducted with malaria-exposed populations from non-African countries. Herein, the seroepidemiological profile against <i>Plasmodium falciparum</i> of naturally exposed individuals from a Brazilian malaria-endemic area against synthetic peptides derived from vaccine candidates circumsporozoite protein (CSP), liver stage antigen-1 (LSA-1), erythrocyte binding antigen-175 (EBA-175), and merozoite surface protein-3 (MSP-3) was investigated. Moreover, human leukocyte antigen (HLA)-DRB1* and HLA-DQB1* were evaluated to characterize genetic modulation of humoral responsiveness to these antigens. The study was performed using blood s"],"journal":["The American journal of tropical medicine and hygiene"],"pagination":["1581-1592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5817778"],"repository":["biostudies-literature"],"pubmed_title":["Synthetic Antigens Derived from <i>Plasmodium falciparum</i> Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area."],"pmcid":["PMC5817778"],"pubmed_authors":["Da Costa Lima-Junior J","Daniel-Ribeiro CT","Arruda M","Banic DM","Ribeiro-Alves M","Pratt-Riccio LR","Santos F","Pratt Riccio EK","Druilhe P","De Souza Perce-Da-Silva D","Camus D","Oliveira-Ferreira J"],"additional_accession":[]},"is_claimable":false,"name":"Synthetic Antigens Derived from <i>Plasmodium falciparum</i> Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area.","description":"Peptide vaccine strategies using <i>Plasmodium</i>-derived antigens have emerged as an attractive approach against malaria. However, relatively few studies have been conducted with malaria-exposed populations from non-African countries. Herein, the seroepidemiological profile against <i>Plasmodium falciparum</i> of naturally exposed individuals from a Brazilian malaria-endemic area against synthetic peptides derived from vaccine candidates circumsporozoite protein (CSP), liver stage antigen-1 (LSA-1), erythrocyte binding antigen-175 (EBA-175), and merozoite surface protein-3 (MSP-3) was investigated. Moreover, human leukocyte antigen (HLA)-DRB1* and HLA-DQB1* were evaluated to characterize genetic modulation of humoral responsiveness to these antigens. The study was performed using blood s","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2025-04-21T22:54:33.642Z","creation":"2019-03-27T00:05:49Z"},"accession":"S-EPMC5817778","cross_references":{"pubmed":["29016339"],"doi":["10.4269/ajtmh.17-0359"]}}