biostudies-literatureUnknown97(5)Pratt-Riccio LRPeptide vaccine strategies using <i>Plasmodium</i>-derived antigens have emerged as an attractive approach against malaria. However, relatively few studies have been conducted with malaria-exposed populations from non-African countries. Herein, the seroepidemiological profile against <i>Plasmodium falciparum</i> of naturally exposed individuals from a Brazilian malaria-endemic area against synthetic peptides derived from vaccine candidates circumsporozoite protein (CSP), liver stage antigen-1 (LSA-1), erythrocyte binding antigen-175 (EBA-175), and merozoite surface protein-3 (MSP-3) was investigated. Moreover, human leukocyte antigen (HLA)-DRB1* and HLA-DQB1* were evaluated to characterize genetic modulation of humoral responsiveness to these antigens. The study was performed using blood sThe American journal of tropical medicine and hygiene1581-1592https://www.ebi.ac.uk/biostudies/studies/S-EPMC5817778biostudies-literatureSynthetic Antigens Derived from <i>Plasmodium falciparum</i> Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area.PMC5817778Da Costa Lima-Junior JDaniel-Ribeiro CTArruda MBanic DMRibeiro-Alves MPratt-Riccio LRSantos FPratt Riccio EKDruilhe PDe Souza Perce-Da-Silva DCamus DOliveira-Ferreira JfalseSynthetic Antigens Derived from <i>Plasmodium falciparum</i> Sporozoite, Liver, and Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen Associations in Individuals Living in a Brazilian Endemic Area.Peptide vaccine strategies using <i>Plasmodium</i>-derived antigens have emerged as an attractive approach against malaria. However, relatively few studies have been conducted with malaria-exposed populations from non-African countries. Herein, the seroepidemiological profile against <i>Plasmodium falciparum</i> of naturally exposed individuals from a Brazilian malaria-endemic area against synthetic peptides derived from vaccine candidates circumsporozoite protein (CSP), liver stage antigen-1 (LSA-1), erythrocyte binding antigen-175 (EBA-175), and merozoite surface protein-3 (MSP-3) was investigated. Moreover, human leukocyte antigen (HLA)-DRB1* and HLA-DQB1* were evaluated to characterize genetic modulation of humoral responsiveness to these antigens. The study was performed using blood s2017-01-01T00:00:00Z2017 Nov2025-04-21T22:54:33.642Z2019-03-27T00:05:49ZS-EPMC58177782901633910.4269/ajtmh.17-0359