{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["NCI NIH HHS"],"pagination":["313-323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5817951"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common malignant brain tumor of childhood. The identification of the 4 molecular subgroups with distinct biological, genetic, and transcriptional features has revolutionized the field of medulloblastoma research over the past 5 years. Despite this, the growing body of research on miRNAs in medulloblastoma has largely focused on the clinical entity of a single disease rather than the molecular subgroups. This review begins by highlighting the role of miRNAs in development and progresses to explore thei"],"journal":["Neuro-oncology"],"pubmed_title":["miR miR on the wall, who's the most malignant medulloblastoma miR of them all?"],"pmcid":["PMC5817951"],"funding_grant_id":["R01 CA148699","R01 CA159859"],"pubmed_authors":["Taylor MD","Kenney AM","Mack S","Garzia L","Zayne K","Wang X","Remke M","Daniels C","Ramaswamy V","Holgado BL","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"miR miR on the wall, who's the most malignant medulloblastoma miR of them all?","description":"microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common malignant brain tumor of childhood. The identification of the 4 molecular subgroups with distinct biological, genetic, and transcriptional features has revolutionized the field of medulloblastoma research over the past 5 years. Despite this, the growing body of research on miRNAs in medulloblastoma has largely focused on the clinical entity of a single disease rather than the molecular subgroups. This review begins by highlighting the role of miRNAs in development and progresses to explore thei","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2025-04-21T22:56:09.699Z","creation":"2019-03-26T22:50:06Z"},"accession":"S-EPMC5817951","cross_references":{"pubmed":["28575493"],"doi":["10.1093/neuonc/nox106"]}}