biostudies-literatureWang XNCI NIH HHS313-323https://www.ebi.ac.uk/biostudies/studies/S-EPMC5817951biostudies-literatureUnknown20(3)microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common malignant brain tumor of childhood. The identification of the 4 molecular subgroups with distinct biological, genetic, and transcriptional features has revolutionized the field of medulloblastoma research over the past 5 years. Despite this, the growing body of research on miRNAs in medulloblastoma has largely focused on the clinical entity of a single disease rather than the molecular subgroups. This review begins by highlighting the role of miRNAs in development and progresses to explore theiNeuro-oncologymiR miR on the wall, who's the most malignant medulloblastoma miR of them all?PMC5817951R01 CA148699R01 CA159859Taylor MDKenney AMMack SGarzia LZayne KWang XRemke MDaniels CRamaswamy VHolgado BLWu XfalsemiR miR on the wall, who's the most malignant medulloblastoma miR of them all?microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common malignant brain tumor of childhood. The identification of the 4 molecular subgroups with distinct biological, genetic, and transcriptional features has revolutionized the field of medulloblastoma research over the past 5 years. Despite this, the growing body of research on miRNAs in medulloblastoma has largely focused on the clinical entity of a single disease rather than the molecular subgroups. This review begins by highlighting the role of miRNAs in development and progresses to explore thei2018-01-01T00:00:00Z2018 Feb2025-04-21T22:56:09.699Z2019-03-26T22:50:06ZS-EPMC58179512857549310.1093/neuonc/nox106