{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Zhang W"],"pubmed_abstract":["<h4>Objective</h4>The objective of the study was to explore the role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer.<h4>Methods</h4>Differential transcription in <i>calgranulin B</i> gene between human papillomavirus (HPV)-positive and negative cervical cancer groups was identified, and the relationship between <i>calgranulin B</i> gene and <i>matrix metalloproteinase</i> (<i>MMP</i>) genes were explored using The Cancer Genome Atlas database. Subsequently, the role of calgranulin B on the cell proliferation, apoptosis, invasion and migration was investigated, through overexpression and/or underexpression of calgranulin B in cervical cancer cells. In addition, the effect of calgranulin B on the growth of the cervical cancer was studied via constructing "],"journal":["Cancer management and research"],"pagination":["323-338"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5818869"],"repository":["biostudies-literature"],"pubmed_title":["The role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer in vitro and in vivo."],"pmcid":["PMC5818869"],"pubmed_authors":["Zhang W","Shen Q","Chen M","Zhu X","Wang Y","Cheng H"],"additional_accession":[]},"is_claimable":false,"name":"The role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer in vitro and in vivo.","description":"<h4>Objective</h4>The objective of the study was to explore the role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer.<h4>Methods</h4>Differential transcription in <i>calgranulin B</i> gene between human papillomavirus (HPV)-positive and negative cervical cancer groups was identified, and the relationship between <i>calgranulin B</i> gene and <i>matrix metalloproteinase</i> (<i>MMP</i>) genes were explored using The Cancer Genome Atlas database. Subsequently, the role of calgranulin B on the cell proliferation, apoptosis, invasion and migration was investigated, through overexpression and/or underexpression of calgranulin B in cervical cancer cells. In addition, the effect of calgranulin B on the growth of the cervical cancer was studied via constructing ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-19T13:17:06.857Z","creation":"2019-03-26T23:05:36Z"},"accession":"S-EPMC5818869","cross_references":{"pubmed":["29497331"],"doi":["10.2147/CMAR.S153036"]}}