biostudies-literatureUnknown10Zhang W<h4>Objective</h4>The objective of the study was to explore the role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer.<h4>Methods</h4>Differential transcription in <i>calgranulin B</i> gene between human papillomavirus (HPV)-positive and negative cervical cancer groups was identified, and the relationship between <i>calgranulin B</i> gene and <i>matrix metalloproteinase</i> (<i>MMP</i>) genes were explored using The Cancer Genome Atlas database. Subsequently, the role of calgranulin B on the cell proliferation, apoptosis, invasion and migration was investigated, through overexpression and/or underexpression of calgranulin B in cervical cancer cells. In addition, the effect of calgranulin B on the growth of the cervical cancer was studied via constructing Cancer management and research323-338https://www.ebi.ac.uk/biostudies/studies/S-EPMC5818869biostudies-literatureThe role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer in vitro and in vivo.PMC5818869Zhang WShen QChen MZhu XWang YCheng HfalseThe role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer in vitro and in vivo.<h4>Objective</h4>The objective of the study was to explore the role of <i>calgranulin B</i> gene on the biological behavior of squamous cervical cancer.<h4>Methods</h4>Differential transcription in <i>calgranulin B</i> gene between human papillomavirus (HPV)-positive and negative cervical cancer groups was identified, and the relationship between <i>calgranulin B</i> gene and <i>matrix metalloproteinase</i> (<i>MMP</i>) genes were explored using The Cancer Genome Atlas database. Subsequently, the role of calgranulin B on the cell proliferation, apoptosis, invasion and migration was investigated, through overexpression and/or underexpression of calgranulin B in cervical cancer cells. In addition, the effect of calgranulin B on the growth of the cervical cancer was studied via constructing 2018-01-01T00:00:00Z20182025-04-19T13:17:06.857Z2019-03-26T23:05:36ZS-EPMC58188692949733110.2147/CMAR.S153036