biostudies-literatureLiu ZYangtze River scholar project, projects of medical and health technology program in Zhejiang provinceNational High-Tech R&amp;D Program of ChinaNational High-Tech R&amp;D Program of China (863 Program)200https://www.ebi.ac.uk/biostudies/studies/S-EPMC5819696biostudies-literatureUnknown18(1)<h4>Background</h4>Minichromosome Maintenance family (MCMs), as replication licensing factors, is involved in the pathogenesis of tumors. Here, we investigated the expression of MCMs and their values in hepatocellular carcinoma (HCC).<h4>Methods</h4>MCMs were analyzed in 105 samples including normal livers (n = 15), cirrhotic livers (n = 40), HCC (n = 50) using quantitative polymerase chain reaction (qPCR) (Cohort 1). Significantly up-regulated MCMs were verified in 102 HCC and matched peritumoral livers using PCR (Cohort 2), and the correlations with clinical features and outcomes were determined. In addition, the focused MCMs were analyzed in parallel immunohistochemistry of 345 samples on spectrum of hepatocarcinogenesis (Cohort 3) and queried for the potential specific role in cell cycBMC cancerMCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression.PMC5819696No.2012AA0202042015KYB151 and 2015117734Zhou LLiu ZLi JChen JXie HZheng SShan QXu XDai HfalseMCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression.<h4>Background</h4>Minichromosome Maintenance family (MCMs), as replication licensing factors, is involved in the pathogenesis of tumors. Here, we investigated the expression of MCMs and their values in hepatocellular carcinoma (HCC).<h4>Methods</h4>MCMs were analyzed in 105 samples including normal livers (n = 15), cirrhotic livers (n = 40), HCC (n = 50) using quantitative polymerase chain reaction (qPCR) (Cohort 1). Significantly up-regulated MCMs were verified in 102 HCC and matched peritumoral livers using PCR (Cohort 2), and the correlations with clinical features and outcomes were determined. In addition, the focused MCMs were analyzed in parallel immunohistochemistry of 345 samples on spectrum of hepatocarcinogenesis (Cohort 3) and queried for the potential specific role in cell cyc2018-01-01T00:00:00Z2018 Feb2025-04-21T14:36:42.406Z2019-03-26T23:03:48ZS-EPMC58196962946321310.1186/s12885-018-4056-8