biostudies-literatureUnknown22(2)Teubl BJUniversity of Graz<h4>Objectives</h4>The design of nanocarriers for local drug administration to the lining mucosa requires a sound knowledge of how nanoparticles (NPs) interact with saliva. This contact determines whether NPs agglomerate and become immobile due to size- and interaction-filtering effects or adsorb on the cell surface and are internalized by epithelial cells. The aim of this study was to examine the behavior of NPs in saliva considering physicochemical NP properties.<h4>Materials and methods</h4>The salivary pore-size distribution was determined, and the viscosity of the fluid inside of the pores was studied with optical tweezers. Distinct functionalized NPs (20 and 200 nm) were dispersed in saliva and salivary buffers and characterized, and surface-bound MUC5B and MUC7 were analyzed by 1D eClinical oral investigations929-940https://www.ebi.ac.uk/biostudies/studies/S-EPMC5820401biostudies-literatureThe effect of saliva on the fate of nanoparticles.PMC5820401Leitinger GKhinast JGFrohlich EPoberaj IStauber RHStojkovic BDocter DRoblegg EPritz EPrassl RTeubl BJfalseThe effect of saliva on the fate of nanoparticles.<h4>Objectives</h4>The design of nanocarriers for local drug administration to the lining mucosa requires a sound knowledge of how nanoparticles (NPs) interact with saliva. This contact determines whether NPs agglomerate and become immobile due to size- and interaction-filtering effects or adsorb on the cell surface and are internalized by epithelial cells. The aim of this study was to examine the behavior of NPs in saliva considering physicochemical NP properties.<h4>Materials and methods</h4>The salivary pore-size distribution was determined, and the viscosity of the fluid inside of the pores was studied with optical tweezers. Distinct functionalized NPs (20 and 200 nm) were dispersed in saliva and salivary buffers and characterized, and surface-bound MUC5B and MUC7 were analyzed by 1D e2018-01-01T00:00:00Z2018 Mar2026-06-07T08:04:01.237Z2025-05-29T19:23:27.536ZS-EPMC58204012869114510.1007/s00784-017-2172-5