{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bullman S"],"funding":["NCATS NIH HHS","Clark Family Fund for GI Cancer Research","Howard Hughes Medical Institute","Project P Fund for Colorectal Cancer Research","National Institutes of Health","Hale Family Center for Pancreatic Cancer","Prevent Cancer Foundation","Cellex Private Foundation","Chambers Family Fund for Colorectal Cancer Research","DF/HCC GI SPORE P50","Banco Bilbao Vizcaya Argentaria Foundation","Stand-up-to-Cancer","National Institute of Health","Team Perry Fund","NCI NIH HHS","American Cancer Society Research Professorship"],"pagination":["1443-1448"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5823247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["358(6369)"],"pubmed_abstract":["Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. <i>Fusobacterium nucleatum</i> is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with <i>Fusobacterium</i> and its associated microbiome-including <i>Bacteroides</i>, <i>Selenomonas</i>, and <i>Prevotella</i> species-is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that <i>Fusobacterium</i> is predominantly associated with cancer cells in the metastatic lesions. Mouse xenografts of human primary colorectal adenocarcinomas were found to retain viable <i>Fusobacterium</i> and its associated micro"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer."],"pmcid":["PMC5823247"],"funding_grant_id":["CA127003","R35 CA197735","CA148894","R35 CA197568","UL1 TR001102","Figdor Family Fellowship","UL1 TR001863","CA169141","K07 CA148894","CA205406","R01 CA118553","CA197735","R01 CA205406","CA118553","CA197568","P50 CA127003","R01 CA169141"],"pubmed_authors":["Fasani R","Elez E","Sicinska E","Mulet N","Pedamallu CS","Huang K","Nuciforo P","Hagan T","Ramon Y Cajal S","Bullman S","Cai D","Ramachandran A","Aguirre AJ","Hahn WC","Ng K","Clancy TE","Walker M","Serna G","Tabernero J","Landolfi S","Ogino S","Chipashvili O","Neuberg D","Nelson T","Guevara F","Zhang X","Fuchs CS","Meyerson M","Diosdado B"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer.","description":"Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. <i>Fusobacterium nucleatum</i> is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with <i>Fusobacterium</i> and its associated microbiome-including <i>Bacteroides</i>, <i>Selenomonas</i>, and <i>Prevotella</i> species-is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that <i>Fusobacterium</i> is predominantly associated with cancer cells in the metastatic lesions. Mouse xenografts of human primary colorectal adenocarcinomas were found to retain viable <i>Fusobacterium</i> and its associated micro","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2026-05-05T03:44:03.249Z","creation":"2019-03-27T00:11:24Z"},"accession":"S-EPMC5823247","cross_references":{"pubmed":["29170280"],"doi":["10.1126/science.aal5240"]}}