{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(2)"],"submitter":["Sasikala M"],"pubmed_abstract":["<h4>Objectives</h4>Altered immune homeostasis and involvement of T cells has been reported in chronic pancreatitis (CP). We evaluated the role of <i>Bach2</i> (BTB and CNC homology basic leucine zipper transcription factor 2), a key regulator of immune homeostasis in the chronicity of CP.<h4>Methods</h4>Expression of <i>Bach2</i> and T-cell transcription factors, enumeration of BACH2+/CD4+ T-lymphocytes were performed by qRT-PCR and flow cytometry respectively. <i>Bach2</i>silenced human CD4+ T-lymphocytes were exposed to CP tissue extract to assess T-cell lineage commitment. Aryl hydrocarbon receptor (<i>Ahr</i>) and Deubiquitinase enzyme A (DUBA/<i>OTUD5gene</i>) were evaluated as markers of persistent Th17 cell differentiation. <i>Bach2</i> gene (exons) was sequenced to identify risk va"],"journal":["United European gastroenterology journal"],"pagination":["272-282"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5833222"],"repository":["biostudies-literature"],"pubmed_title":["Bach2 repression mediates Th17 cell induced inflammation and associates with clinical features of advanced disease in chronic pancreatitis."],"pmcid":["PMC5833222"],"pubmed_authors":["Murali Manohar K","Ghosh S","Aslam M","Pavan Kumar P","Pradeep R","Talukdar R","Reddy DN","Deshpande N","Rao GV","Ravikanth VV","Singh S","Sasikala M"],"additional_accession":[]},"is_claimable":false,"name":"Bach2 repression mediates Th17 cell induced inflammation and associates with clinical features of advanced disease in chronic pancreatitis.","description":"<h4>Objectives</h4>Altered immune homeostasis and involvement of T cells has been reported in chronic pancreatitis (CP). We evaluated the role of <i>Bach2</i> (BTB and CNC homology basic leucine zipper transcription factor 2), a key regulator of immune homeostasis in the chronicity of CP.<h4>Methods</h4>Expression of <i>Bach2</i> and T-cell transcription factors, enumeration of BACH2+/CD4+ T-lymphocytes were performed by qRT-PCR and flow cytometry respectively. <i>Bach2</i>silenced human CD4+ T-lymphocytes were exposed to CP tissue extract to assess T-cell lineage commitment. Aryl hydrocarbon receptor (<i>Ahr</i>) and Deubiquitinase enzyme A (DUBA/<i>OTUD5gene</i>) were evaluated as markers of persistent Th17 cell differentiation. <i>Bach2</i> gene (exons) was sequenced to identify risk va","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-05-05T03:46:19.574Z","creation":"2026-04-07T21:22:01.961Z"},"accession":"S-EPMC5833222","cross_references":{"pubmed":["29511557"],"doi":["10.1177/2050640617716596"]}}