{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kappler M"],"funding":["Wilhelm Sander-Stiftung"],"pagination":["6-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5833914"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["<h4>Background and purpose</h4>Hypoxia gene expression signatures are of high prognostic value for head and neck cancer patients. Recently, the prognostic information of a multiple-gene hypoxia signature was found to be provided by the mRNA level of <i>P4HA1</i> alone (Tawk et al., 2016). Therefore, we studied the prognostic value of <i>P4HA1</i> in an independent cohort of oral squamous cell carcinoma (OSCC) patients.<h4>Material and methods</h4>Frozen tumor samples of 118 adult OSCC patients were analysed for <i>P4HA1</i> mRNA level by quantitative real-time TaqMan™ PCR analysis. Kaplan-Meier analysis and Cox's regression analysis were performed to characterize the prognostic impact of <i>P4HA1</i> mRNA level in OSCC patients.<h4>Results</h4>The analyzed patient cohort was divided into f"],"journal":["Clinical and translational radiation oncology"],"pubmed_title":["P4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients."],"pmcid":["PMC5833914"],"funding_grant_id":["FKZ: 2013.090.1"],"pubmed_authors":["Bethmann D","Gallwitz L","Guttler A","Kessler J","Kappler M","Horter S","Taubert H","Eckert AW","Bache M","Kaune T","Kotrba J","Vordermark D","Bilkenroth U","Greither T","Rot S","Wichmann H"],"additional_accession":[]},"is_claimable":false,"name":"P4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients.","description":"<h4>Background and purpose</h4>Hypoxia gene expression signatures are of high prognostic value for head and neck cancer patients. Recently, the prognostic information of a multiple-gene hypoxia signature was found to be provided by the mRNA level of <i>P4HA1</i> alone (Tawk et al., 2016). Therefore, we studied the prognostic value of <i>P4HA1</i> in an independent cohort of oral squamous cell carcinoma (OSCC) patients.<h4>Material and methods</h4>Frozen tumor samples of 118 adult OSCC patients were analysed for <i>P4HA1</i> mRNA level by quantitative real-time TaqMan™ PCR analysis. Kaplan-Meier analysis and Cox's regression analysis were performed to characterize the prognostic impact of <i>P4HA1</i> mRNA level in OSCC patients.<h4>Results</h4>The analyzed patient cohort was divided into f","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2025-04-19T15:18:05.371Z","creation":"2019-03-26T23:22:37Z"},"accession":"S-EPMC5833914","cross_references":{"pubmed":["29594211"],"doi":["10.1016/j.ctro.2017.05.002"]}}