biostudies-literatureKappler MWilhelm Sander-Stiftung6-11https://www.ebi.ac.uk/biostudies/studies/S-EPMC5833914biostudies-literatureUnknown5<h4>Background and purpose</h4>Hypoxia gene expression signatures are of high prognostic value for head and neck cancer patients. Recently, the prognostic information of a multiple-gene hypoxia signature was found to be provided by the mRNA level of <i>P4HA1</i> alone (Tawk et al., 2016). Therefore, we studied the prognostic value of <i>P4HA1</i> in an independent cohort of oral squamous cell carcinoma (OSCC) patients.<h4>Material and methods</h4>Frozen tumor samples of 118 adult OSCC patients were analysed for <i>P4HA1</i> mRNA level by quantitative real-time TaqMan™ PCR analysis. Kaplan-Meier analysis and Cox's regression analysis were performed to characterize the prognostic impact of <i>P4HA1</i> mRNA level in OSCC patients.<h4>Results</h4>The analyzed patient cohort was divided into fClinical and translational radiation oncologyP4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients.PMC5833914FKZ: 2013.090.1Bethmann DGallwitz LGuttler AKessler JKappler MHorter STaubert HEckert AWBache MKaune TKotrba JVordermark DBilkenroth UGreither TRot SWichmann HfalseP4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients.<h4>Background and purpose</h4>Hypoxia gene expression signatures are of high prognostic value for head and neck cancer patients. Recently, the prognostic information of a multiple-gene hypoxia signature was found to be provided by the mRNA level of <i>P4HA1</i> alone (Tawk et al., 2016). Therefore, we studied the prognostic value of <i>P4HA1</i> in an independent cohort of oral squamous cell carcinoma (OSCC) patients.<h4>Material and methods</h4>Frozen tumor samples of 118 adult OSCC patients were analysed for <i>P4HA1</i> mRNA level by quantitative real-time TaqMan™ PCR analysis. Kaplan-Meier analysis and Cox's regression analysis were performed to characterize the prognostic impact of <i>P4HA1</i> mRNA level in OSCC patients.<h4>Results</h4>The analyzed patient cohort was divided into f2017-01-01T00:00:00Z2017 Aug2025-04-19T15:18:05.371Z2019-03-26T23:22:37ZS-EPMC58339142959421110.1016/j.ctro.2017.05.002