{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Haaland OA"],"pubmed_abstract":["<b>Background:</b> It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these gene-environment (GxE) interactions at a genome-wide level is still lacking for isolated CL/P. <b>Materials and Methods:</b> We used our R-package Haplin to perform a genome-wide search for GxE effects in isolated CL/P. From a previously published GWAS, genotypes and information on maternal periconceptional cigarette smoking, alcohol intake, and vitamin use were available on 1908 isolated CL/P triads of predominantly European or Asian ancestry. A GxE effect is present if the relative risk estimates for gene-effects in the offspring are different across exposure strata. We t"],"journal":["Frontiers in genetics"],"pagination":["60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5834486"],"repository":["biostudies-literature"],"pubmed_title":["A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in <i>ESRRG</i>."],"pmcid":["PMC5834486"],"pubmed_authors":["Gjerdevik M","Haaland OA","Gjessing HK","Lie RT","Romanowska J","Jugessur A"],"additional_accession":[]},"is_claimable":false,"name":"A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in <i>ESRRG</i>.","description":"<b>Background:</b> It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these gene-environment (GxE) interactions at a genome-wide level is still lacking for isolated CL/P. <b>Materials and Methods:</b> We used our R-package Haplin to perform a genome-wide search for GxE effects in isolated CL/P. From a previously published GWAS, genotypes and information on maternal periconceptional cigarette smoking, alcohol intake, and vitamin use were available on 1908 isolated CL/P triads of predominantly European or Asian ancestry. A GxE effect is present if the relative risk estimates for gene-effects in the offspring are different across exposure strata. We t","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-04-08T01:04:51.33Z","creation":"2019-03-26T23:17:50Z"},"accession":"S-EPMC5834486","cross_references":{"pubmed":["29535761"],"doi":["10.3389/fgene.2018.00060"]}}