{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["158(2)"],"submitter":["Mesnage R"],"pubmed_abstract":["Plasticizers with estrogenic activity, such as bisphenol A (BPA), have potential adverse health effects in humans. Due to mounting evidence of these health effects, BPA is being phased out and replaced by other bisphenol variants in \"BPA-free\" products. We have compared estrogenic activity of BPA with 6 bisphenol analogues [bisphenol S (BPS); bisphenol F (BPF); bisphenol AP (BPAP); bisphenol AF (BPAF); bisphenol Z (BPZ); bisphenol B (BPB)] in 3 human breast cancer cell lines. Estrogenicity was assessed (10-11-10-4 M) by cell growth in an estrogen receptor (ER)-mediated cell proliferation assay, and by the induction of estrogen response element-mediated transcription in a luciferase assay. BPAF was the most potent bisphenol, followed by BPB > BPZ ∼ BPA > BPF ∼ BPAP > BPS. The addition of IC"],"journal":["Toxicological sciences : an official journal of the Society of Toxicology"],"pagination":["431-443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5837682"],"repository":["biostudies-literature"],"pubmed_title":["Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells."],"pmcid":["PMC5837682"],"pubmed_authors":["Balu S","Antoniou MN","Phedonos A","Arno M","Mesnage R","Corton JC"],"additional_accession":[]},"is_claimable":false,"name":"Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.","description":"Plasticizers with estrogenic activity, such as bisphenol A (BPA), have potential adverse health effects in humans. Due to mounting evidence of these health effects, BPA is being phased out and replaced by other bisphenol variants in \"BPA-free\" products. We have compared estrogenic activity of BPA with 6 bisphenol analogues [bisphenol S (BPS); bisphenol F (BPF); bisphenol AP (BPAP); bisphenol AF (BPAF); bisphenol Z (BPZ); bisphenol B (BPB)] in 3 human breast cancer cell lines. Estrogenicity was assessed (10-11-10-4 M) by cell growth in an estrogen receptor (ER)-mediated cell proliferation assay, and by the induction of estrogen response element-mediated transcription in a luciferase assay. BPAF was the most potent bisphenol, followed by BPB > BPZ ∼ BPA > BPF ∼ BPAP > BPS. The addition of IC","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-04-07T19:32:43.89Z","creation":"2019-03-26T23:06:54Z"},"accession":"S-EPMC5837682","cross_references":{"pubmed":["28591870"],"doi":["10.1093/toxsci/kfx101"]}}