{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jacquet-Guibon S"],"funding":["Agence Nationale de la Recherche"],"pagination":["e0191796"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5844532"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["A randomized controlled trial was performed on racing horses, to evaluate the efficacy of a new class of therapeutic agents in regenerative medicine-ReGeneraTing Agents® (RGTA®), to treat tendinopathies. Preliminary uncontrolled studies on tendon healing in racing horses with RGTA® (OTR4131)-Equitend® showed encouraging results, justifying performing a randomized, controlled, multicenter study with a two-year racing performance follow up. The objective of this study was to evaluate the effect of Equitend® versus placebo on acute superficial digital flexor tendonitis in racing French Standardbred Trotters (ST). Twenty-two ST were randomly and blindly assigned to receive with a ratio of 2 to 1, a single Equitend® (n = 14) or placebo (n = 8) intralesional injection under ultrasonographic guid"],"journal":["PloS one"],"pubmed_title":["Randomized controlled trial demonstrates the benefit of RGTA® based matrix therapy to treat tendinopathies in racing horses."],"pmcid":["PMC5844532"],"funding_grant_id":["ANR-08-BIOT-0021"],"pubmed_authors":["Barritault D","Jacquet-Guibon S","Crevier-Denoix N","Chiappini F","Sineriz F","Coudry V","Denoix JM","Leroy S","Dupays AG"],"additional_accession":[]},"is_claimable":false,"name":"Randomized controlled trial demonstrates the benefit of RGTA® based matrix therapy to treat tendinopathies in racing horses.","description":"A randomized controlled trial was performed on racing horses, to evaluate the efficacy of a new class of therapeutic agents in regenerative medicine-ReGeneraTing Agents® (RGTA®), to treat tendinopathies. Preliminary uncontrolled studies on tendon healing in racing horses with RGTA® (OTR4131)-Equitend® showed encouraging results, justifying performing a randomized, controlled, multicenter study with a two-year racing performance follow up. The objective of this study was to evaluate the effect of Equitend® versus placebo on acute superficial digital flexor tendonitis in racing French Standardbred Trotters (ST). Twenty-two ST were randomly and blindly assigned to receive with a ratio of 2 to 1, a single Equitend® (n = 14) or placebo (n = 8) intralesional injection under ultrasonographic guid","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-05-29T22:10:46.347Z","creation":"2025-05-29T22:10:46.347Z"},"accession":"S-EPMC5844532","cross_references":{"pubmed":["29522564"],"doi":["10.1371/journal.pone.0191796"]}}